ARV drugs are in use since the last three decades for postexposure prophylaxis following occupational exposure to HIV, but more recently, the same has been extended to accidental exposure like unprotected intercourse, sexual assault, needle prick injuries, IV drug users, etc. Use of ART for postexposure prophylaxis is supported by animal studies , a case control study , and systematic reviews which have demonstrated reduced risk of acquiring chronic infection and cost-effectiveness in high-risk groups [3, 4]. That ARV drugs are effective in postexposure prophylaxis is further supported by their role in preexposure prophylaxis and in preventing mother-to-child transmission.
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