Molecular Virology and Life Cycle

  • Darren J. Wong
  • Stephen A. LocarniniEmail author


The hepatitis B virus is a prevalent human infection with no cure at present. It is a significant cause of global morbidity and mortality and has achieved its persistence in humans via its complex life cycle and ability to use its few protein products in a multifunctional manner to subvert and evade immune detection and clearance. These aspects of the virus are discussed in detail, as are the development of clinically important mutations in the viral genome that develop as a result of host immune selection, as well as those selected by the introduction of antiviral therapy or vaccination.


Hepatitis B Molecular Virology Lifecycle Antiviral Resistance 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of GastroenterologySt. Vincent’s Hospital, MelbourneFitzroyAustralia
  2. 2.Department of Molecular Research and DevelopmentVictorian Infectious Diseases Reference LaboratoryMelbourneAustralia

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