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Application of Nanotechnology for Cancer Treatment

  • Monika Verma
  • Promila Sheoran
  • Ashok Chaudhury
Chapter

Abstract

Cancer has become a big threat to mankind worldwide. This disease is the second most common disease with maximum mortality. According to the recent report from ICMR, 1300 people die every day in India because of cancer. Despite having good progress in diagnosis as well as in treatment, cancer is still a big nuance to our society. It has become more and more clearer in the recent times and evident that the development of new drugs alone is not enough for ensuring progress in drug therapy. This is why to achieve high intra-tumor drug concentration along with minimum exposure of drugs to normal tissue is the most important goal of anticancer drug delivery. These problems can be overcome by using nanoparticles for their delivery. It enhances the permeability and retention onto the tumor cells and not onto healthy cells. It also helps in delivering the slow and controlled release to the targeted cells. Drug carriers in nanoscale offer the chances of enhancing the therapeutic index of drug molecules by diminishing their toxicity against physiological tissues and achieving controlled therapeutic levels of the drug for a long time. It would minimize the concentration of drug intake and maximize the overall profile of absorption, biodistribution, metabolism, and excretion (ADME) profile.

Notes

Acknowledgements

This work was supported by Department of Science and Technology, Ministry of Science and Technology, Government of India, New Delhi for providing financial assistance under Nano Mission program vide Sanction Letter # SR/NM/PG-01/2007 and University Grants Commission, New Delhi, India vide Sanction Letter # F-3-18/2009 dated 31st March, 2009 and Sanction Letter # F-3-4/2016/DRS-II (SAP-II) dated 1st April 2016 under Special Assistance Program (SAP) DRS-I and SAP DRS-II Program.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Monika Verma
    • 1
  • Promila Sheoran
    • 1
  • Ashok Chaudhury
    • 1
  1. 1.Department of Bio & Nano Technology, Bio & Nano Technology CentreGuru Jambheshwar University of Science & TechnologyHisarIndia

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