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Molecular Mechanisms of Lymph Node Metastasis

  • Naohide Oue
  • Yasuhiko Kitadai
  • Wataru YasuiEmail author
Chapter

Abstract

Despite improvements in diagnostic and therapeutic modalities, the prognosis of advanced cancer with extensive invasion and metastasis remains poor. The severity of a clinical prognosis depends on whether lymph node metastasis has occurred. For metastasis to occur, tumor cells must undergo a multistep process through a series of sequential and selective events. The metastatic process consists of detachment, local invasion, motility, lymphangiogenesis, lymphatic vessel invasion, survival in the circulation, adhesion to endothelial cells, extravasation, and regrowth in lymph nodes. Among them, the most important process is lymphangiogenesis, which is regulated by members of the vascular endothelial growth factor (VEGF) family and their receptors. In addition to lymphangiogenesis, it is well accepted that cancer stem cells play a significant role in metastasis. Although several types of metastasis-associated molecules have been identified, the expression of these molecules differs among esophageal, gastric, and colorectal cancer. This chapter will review the cellular and molecular mechanisms of lymph node metastasis including lymphangiogenesis and cancer stem cells in these human cancer types.

Keywords

VEGF PDGF Migration Cancer stem cell 

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Molecular PathologyHiroshima University Institute of Biomedical and Health SciencesHiroshimaJapan

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