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Effect of H64V Mutation on the Dynamical Properties of Human Neuroglobin: A Simulation Study

  • T. L. Quyen Bui
  • V. Tuyen Hoang
  • T.-L. Hoai Nguyen
  • V. Thanh Ngo
Conference paper
Part of the IFMBE Proceedings book series (IFMBE, volume 63)

Abstract

In this work, we present a classical molecular dynamical simulation of human neuroglobin (Ngb) proteins with and without mutation at the distal position. Our aim is to investigate the role of the distal residue in the stability of Ngb. The simulation has been performed using Gromacs software with Gromos96 force field. We designed a mutant Ngb by mutating histidine His64 residue to valine residue. The results showed that, the mutant H64V would lead to the less stability in the inner structure of the proteins. Moreover, the mutation strongly affects the properties of the heme group. Obvious changes in the high-order structure of the mutant protein can also be observed.

Keywords

Neuroglobin Mutation MD simulation 

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Notes

Acknowledgements

This work was supported by the Lotus program, Grand No. 45/2012/HD-NDT. We thank S. Bernad and V. Derrien for fruitfully discussion, and A-.T-.V. Nguyen for carefully reading of the manuscript.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • T. L. Quyen Bui
    • 1
  • V. Tuyen Hoang
    • 2
  • T.-L. Hoai Nguyen
    • 2
  • V. Thanh Ngo
    • 2
  1. 1.Thai Binh University of Medicine and PharmacyThai BinhVietnam
  2. 2.Institute of PhysicsVASTBa Dinh, HanoiVietnam

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