The Effects of Simvastatin on Osseo-Integration Around Titanium Implants in Posterior Maxilla of Osteoporotic Rats

  • N. Doan
  • Z. Du
  • J. Xiao
  • P. Reher
  • W. Xia
  • R. Crawford
  • P. Reher
  • S. Ivanovski
  • F. Yang
  • Q. T. Duong
  • J. Jiang
  • Y. Xiao
Conference paper
First Online:
Part of the IFMBE Proceedings book series (IFMBE, volume 63)

Abstract

Objective This study aims to evaluate the relationship between implant placement, poor quality bone, simvastatin, and osseo-integration of surface-treated implants in the posterior maxilla of osteoporotic rats. Materials and methods Sixty-four female Sprague-Dawley rats, aged 3 months old were used in this study, divided into three groups: Sham-operated (SHAM; n = 20), ovariectomized (OVX; n = 20) and ovariectomized treated with simvastatin (OVX + SIM; n = 20). Two rats from the SHAM and two from the OVX groups were used to verify osteoporosis. Eighty-four days following ovariectomy, screw-shaped titanium implants were immediately placed into mesial root sockets of the posterior maxilla. Simvastatin was administered orally at 5 mg/kg each day after the implant placement in the OVX + SIM group. The animals were sacrificed at either 28 or 56 days from the date of implant insert and the undecalcified tissue sections were processed for histological analysis. The osseo-integration indices used were: bone formation rate (BFR), bone to implant contact (BIC), and bone density (BD). Results The osseo-integration indices (BFR, BIC and BD) in the three groups demonstrated significant differences among the SHAM > OVX + SIM > OVX group, which implied that simvastatin could promote bone mineralization in OVX rats. Conclusion This study shows for the first time that simvastatin can positively affect the osseo-integration indices, and successfully promoted osseo-integration in the posterior maxilla in OP rats.

Keywords

Simvastatin Dental implants Osteoporosis Posterior maxilla Rats 
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Notes

Acknowledgements

This research is a collaboration effort from Queensland University of Technology, Australia, Griffith University, Australia, and Fujian Medical University, China, the ITI Foundation, Switzerland, the Australian Dental Research Foundation, and the kind donation by Southern Implant® of the implants used in this study.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • N. Doan
    • 1
    • 4
  • Z. Du
    • 1
  • J. Xiao
    • 2
  • P. Reher
    • 2
  • W. Xia
    • 3
  • R. Crawford
    • 1
  • P. Reher
    • 2
  • S. Ivanovski
    • 2
  • F. Yang
    • 3
  • Q. T. Duong
    • 1
  • J. Jiang
    • 3
  • Y. Xiao
    • 1
  1. 1.Institute of Health and Biomedical InnovationQueensland University of TechnologyBrisbaneAustralia
  2. 2.School of Dentistry and Oral HealthGriffith UniversityGold CoastAustralia
  3. 3.Department of Oral ImplantsAffiliated Stomatological Hospital of Fujian MedicalFuzhouChina
  4. 4.School of DentistryThe University of QueenslandBrisbaneAustralia

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