Antimicrobial Agents from Plants

  • Reshma Reghu
  • Pramod Sahadevan
  • Shiburaj Sugathan
Chapter

Abstract

Plants represent an inexhaustible source of novel molecules for recent drug discovery studies. Plant extracts and their active constituents have long been used in traditional medicine for the treatment of several diseases. The emergence of antibiotic-resistant microbial strains and the resurgence of newer and more deadly diseases have called for the need to discover novel antimicrobials. The entire natural resources are being screened in a rapid pace to identify potential drug leads. Recent advances in the development of techniques for isolation, characterization and pharmacological evaluation have led to an interest in plant secondary metabolites as a source of new drugs. Natural product research is continuously exploring the chemical diversity of several lead molecules, which can be used as templates for new drug discovery. This chapter will focus on the significance of plant derived compounds for the development of novel antimicrobial agents.

Keywords

Natural products Antimicrobials Phytochemicals 

References

  1. Achenbach H, Waibel R, Nkunya MHH, Weenen H (1992) Antimalarial compounds from Hoslundia opposita. Phytochemistry 31:3781–3784CrossRefGoogle Scholar
  2. Afolayan AJ, Meyer JJM (1997) The antimicrobial activity of 3,5,7-trihydroxyflavone isolated from the shoots of Helichrysum aureonitens. J Ethnopharmacol 57:177–181PubMedCrossRefGoogle Scholar
  3. Amaral JA, Ekins A, Richards SR, Knowles R (1998) Effect of selected monoterpenes on methane oxidation, denitrification, and aerobic metabolism by bacteria in pure culture. Appl Environ Microbiol 64:520–525PubMedPubMedCentralGoogle Scholar
  4. Araujo MGF, Hilário F, Nogueira LG, Vilegas W, Santos LC, Bauab TM (2011) Chemical constituents of the methanolic extract of leaves of Leiothrix spiralis Ruhland and their antimicrobial activity. Molecules 16:10479–10490PubMedCrossRefGoogle Scholar
  5. Artini M, Papa R, Barbato G, Scoarughi GL, Cellini A, Morazzoni P, Bombardelli E, Selan L (2012) Bacterial biofilm formation inhibitory activity revealed for plant derived natural compounds. Bioorg Med Chem 20:920–926PubMedCrossRefGoogle Scholar
  6. Atta-ur-Rahman n, Choudhary MI (1999) Diterpenoid and steroidal alkaloids. Nat Prod Rep 16:619–635PubMedCrossRefGoogle Scholar
  7. Ayafor JF, Tchuendem MH, Nyasse B, Tillequin F, Anke H (1994) Novel bioactive diterpenoids from Aframomum aulacocarpos. J Nat Prod 57:917–923PubMedCrossRefGoogle Scholar
  8. Barber MS, McConnell VS, DeCaux BS (2000) Antimicrobial intermediates of the general phenylpropanoid and lignin specific pathways. Phytochemistry 54:53–56PubMedCrossRefGoogle Scholar
  9. Basile A, Sorbo S, Spadaro V, Bruno M, Maggio A, Faraone N, Rosselli S (2009) Antimicrobial and antioxidant activities of coumarins from the roots of Ferulago campestris (Apiaceae). Molecules 14:939–952PubMedCrossRefGoogle Scholar
  10. Berkada B (1978) Preliminary report on warfarin for the treatment of herpes simplex. J Irish Coll Physicians Surg 22:56Google Scholar
  11. Beuria TK, Santra MK, Panda D (2005) Sanguinarine blocks cytokinesis in bacteria by inhibiting FtsZ assembly and bundling. Biochemistry 44:16584–16593PubMedCrossRefGoogle Scholar
  12. Boberek JM, Stach J, Good L (2010) Genetic evidence for inhibition of bacterial division protein FtsZ by berberine. PLoS One 5:e13745PubMedPubMedCentralCrossRefGoogle Scholar
  13. Borris RP (1996) Natural products research: perspectives from a major pharmaceutical company. J Ethnopharmacol 51:29–38PubMedCrossRefGoogle Scholar
  14. Brandão MG, Krettli AU, Soares LS, Nery CG, Marinuzzi HC (1997) Antimalarial activity of extracts and fractions from Bidens pilosa and other Bidens species (Asteraceae) correlated with the presence of acetylene and flavonoid compounds. J Ethnopharmacol 57:131–138PubMedCrossRefGoogle Scholar
  15. Burt S (2004) Essential oils: their antibacterial properties and potential applications in foods--a review. Int J Food Microbiol 94:223–253PubMedCrossRefGoogle Scholar
  16. Burt SA, Reinders RD (2003) Antibacterial activity of selected plant essential oils against Escherichia coli O157:H7. Lett Appl Microbiol 36:162–167PubMedCrossRefGoogle Scholar
  17. Chen K, Shi Q, Kashiwada Y, Zhang DC, Hu CQ, Jin JQ, Nozaki H, Kilkuskie RE, Tramontano E, Cheng YC (1992) Anti-aids agents, 6. Salaspermic acid, an anti-HIV principle from Tripterygium wilfordii, and the structure-activity correlation with its related compounds. J Nat Prod 55:340–346PubMedCrossRefGoogle Scholar
  18. Chinsembu KC, Hedimbi M (2009) A Survey of Plants with Anti-HIV Active Compounds and their Modes of Action. Med J Zambia 36:178–186Google Scholar
  19. Chong KP, Rossall S, Atong M (2009) In Vitro Antimicrobial Activity and Fungi toxicity of Syringic Acid, Caffeic Acid and 4-hydroxybenzoic Acid against Ganoderma boninense. J Agric Sci 1:15–20Google Scholar
  20. Chorianopoulos NG, Giaouris ED, Skandamis PN, Haroutounian SA, Nychas GJE (2008) Disinfectant test against monoculture and mixed-culture biofilms composed of technological, spoilage and pathogenic bacteria: bactericidal effect of essential oil and hydrosol of Satureja thymbra and comparison with standard acid-base sanitizers. J Appl Microbiol 104:1586–1596PubMedCrossRefGoogle Scholar
  21. Chung KT, Lu Z, Chou MW (1998a) Mechanism of inhibition of tannic acid and related compounds on the growth of intestinal bacteria. Food Chem Toxicol 36:1053–1060PubMedCrossRefGoogle Scholar
  22. Chung KT, Wong TY, Wei CI, Huang YW, Lin Y (1998b) Tannins and human health: a review. Crit Rev Food Sci Nutr 38:421–464PubMedCrossRefGoogle Scholar
  23. Cichewicz RH, Thorpe PA (1996) The antimicrobial properties of chile peppers (Capsicum species) and their uses in Mayan medicine. J Ethnopharmacol 52:61–70PubMedCrossRefGoogle Scholar
  24. Cobrado L, Azevedo MM, Silva-Dias A, Ramos JP, Pina-Vaz C, Rodrigues AG (2012) Cerium, chitosan and hamamelitannin as novel biofilm inhibitors? J Antimicrob Chemother 67:1159–1162PubMedCrossRefGoogle Scholar
  25. Cook NC, Sammam S (1996) Flavonoids- Chemistry, metabolism, cardio protective effects and dietary sources. Nutr Biochem 7:66–76CrossRefGoogle Scholar
  26. Cowan MM (1999) Plant products as antimicrobial agents. Clin Microbiol Rev 12:564–582PubMedPubMedCentralGoogle Scholar
  27. Critchfield JW, Butera ST, Folks TM (1996) Inhibition of HIV activation in latently infected cells by flavonoid compounds. AIDS Res Hum Retroviruses 12:39–46PubMedCrossRefGoogle Scholar
  28. Cushnie TPT, Lamb AJ (2005) Antimicrobial activity of flavonoids. Int J Antimicrob Agents 26:343–356PubMedCrossRefGoogle Scholar
  29. Davidson PM (2001) Chemical preservatives and naturally antimicrobial compounds. In: Beuchat MP, Montville LR (eds) Food microbiology. Fundamentals and frontiers, 2nd edn. ASM Press, Washington, DC, pp 593–628Google Scholar
  30. De Bolle MF, Osborn RW, Goderis IJ, Noe L, Acland D, Hart CA, Torrekens S, Van Leuven F, Broekaert WF (1996) Antimicrobial peptides from Mirabilis jalapa and Amaranthus caudatus: expression, processing, localization and biological activity in transgenic tobacco. Plant Mol Biol 31:993–1008PubMedCrossRefGoogle Scholar
  31. De Pasquale R, Germanò MP, Keita A, Sanogo R, Iauk L (1995) Antiulcer activity of Pteleopsis suberosa. J Ethnopharmacol 47:55–58PubMedCrossRefGoogle Scholar
  32. Devi KP, Nisha SA, Sakthivel R, Pandian SK (2010) Eugenol (an essential oil of clove) acts as an antibacterial agent against Salmonella typhi by disrupting the cellular membrane. J Ethnopharmacol 130:107–115PubMedCrossRefGoogle Scholar
  33. Domadia P, Swarup S, Bhunia A, Sivaraman J, Dasgupta D (2007) Inhibition of bacterial cell division protein FtsZ by cinnamaldehyde. Biochem Pharmacol 74:831–840PubMedCrossRefGoogle Scholar
  34. Domadia PN, Bhunia A, Sivaraman J, Swarup S, Dasgupta D (2008) Berberine targets assembly of Escherichia coli cell division protein FtsZ. Biochemistry 47:3225–3234PubMedCrossRefGoogle Scholar
  35. Donlan RM (2002) Biofilms: microbial life on surfaces. Emerg Infect Dis 8:881–890PubMedPubMedCentralCrossRefGoogle Scholar
  36. Duke JA (1985) Handbook of medicinal herbs. CRC Press, Inc., BocaRatonGoogle Scholar
  37. Eloff JN (1998) Which extractant should be used for the screening and isolation of antimicrobial components from plants? J Ethnopharmacol 60:1–8PubMedCrossRefGoogle Scholar
  38. Fernández MA, García MD, Sáenz MT (1996) Antibacterial activity of the phenolic acids fractions of Scrophularia frutescens and Scrophularia sambucifolia. J Ethnopharmacol 53:11–14PubMedCrossRefGoogle Scholar
  39. Fernandez de Caleya R, Gonzalez-Pascual B, García-Olmedo F, Carbonero P (1972) Susceptibility of phytopathogenic bacteria to wheat purothionins in vitro. Appl Microbiol 23:998–1000PubMedGoogle Scholar
  40. Fesen MR, Kohn KW, Leteurtre F, Pommier Y (1993) Inhibitors of human immunodeficiency virus integrase. Proc Natl Acad Sci U S A 90:2399–2403PubMedPubMedCentralCrossRefGoogle Scholar
  41. Freiburghaus F, Kaminsky R, Nkunya MH, Brun R (1996) Evaluation of African medicinal plants for their in vitro trypanocidal activity. J Ethnopharmacol 55:1–11PubMedCrossRefGoogle Scholar
  42. Frémont L (2000) Biological effects of resveratrol. Life Sci 66:663–673PubMedCrossRefGoogle Scholar
  43. Fujioka T, Kashiwada Y, Kilkuskie RE, Cosentino LM, Ballas LM, Jiang JB, Janzen WP, Chen IS, Lee KH (1994) Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. J Nat Prod 57:243–247PubMedCrossRefGoogle Scholar
  44. García A, Bocanegra-García V, Palma-Nicolás JP, Rivera G (2012) Recent advances in antitubercular natural products. Eur J Med Chem 49:1–23PubMedCrossRefGoogle Scholar
  45. Ghoshal S, Prasad BN, Lakshmi V (1996) Antiamoebic activity of Piper longum fruits against Entamoeba histolytica in vitro and in vivo. J Ethnopharmacol 50:167–170PubMedCrossRefGoogle Scholar
  46. Giordani R, Siepaio M, Moulin-Traffort J, Régli P (1991) Antifungal action of Carica papaya latex: isolation of fungal cell wall hydrolysing enzymes. Mycoses 34:469–477PubMedCrossRefGoogle Scholar
  47. Giordani R, Trebaux J, Masi M, Regli P (2001) Enhanced antifungal activity of ketoconazole by Euphorbia characias latex against Candida albicans. J Ethnopharmacol 78:1–5PubMedCrossRefGoogle Scholar
  48. Gutierrez J, Barry-Ryan C, Bourke P (2008) The antimicrobial efficacy of plant essential oil combinations and interactions with food ingredients. Int J Food Microbiol 124:91–97PubMedCrossRefGoogle Scholar
  49. Habtemariam S, Gray AI, Waterman PG (1993) A new antibacterial sesquiterpene from Premna oligotricha. J Nat Prod 56:140–143PubMedCrossRefGoogle Scholar
  50. Haslam E (1996) Natural polyphenols (vegetable tannins) as drugs: possible modes of action. J Nat Prod 59:205–215PubMedCrossRefGoogle Scholar
  51. Helander IM, Alakomi HL, Latva-Kala K, Koski P (1997) Polyethyleneimine is an effective permeabilizer of gram-negative bacteria. Microbiology 143(Pt 10):3193–3199PubMedCrossRefGoogle Scholar
  52. Houghton PJ, Woldemariam TZ, Khan AI, Burke A, Mahmood N (1994) Antiviral activity of natural and semi-synthetic chromone alkaloids. Antiviral Res 25:235–244PubMedCrossRefGoogle Scholar
  53. Hoult JR, Payá M (1996) Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. Gen Pharmacol 27:713–722PubMedCrossRefGoogle Scholar
  54. Hudson JB, Balza F, Harris L, Towers GH (1993a) Light-mediated activities of thiarubrines against human immunodeficiency virus. Photochem Photobiol 57:675–680PubMedCrossRefGoogle Scholar
  55. Hudson JB, Graham EA, Harris L, Ashwood-Smith MJ (1993b) The unusual UVA-dependent antiviral properties of the furoisocoumarin, coriandrin. Photochem Photobiol 57:491–496PubMedCrossRefGoogle Scholar
  56. Hufford CD, Jia Y, Croom EM, Muhammed I, Okunade AL, Clark AM, Rogers RD (1993) Antimicrobial compounds from Petalostemum purpureum. J Nat Prod 56:1878–1889PubMedCrossRefGoogle Scholar
  57. Hwang D, Lim YH (2015) Resveratrol antibacterial activity against Escherichia coli is mediated by Z-ring formation inhibition via suppression of FtsZ expression. Sci Rep 5:10029PubMedPubMedCentralCrossRefGoogle Scholar
  58. Ingólfsson HI, Thakur P, Herold KF, Ashley Hobart E, Ramsey NB, Periole X, de Jong DH, Zwama M, Yilmaz D, Hall K, Maretzky T, Hemmings HC Jr, Blobel C, Marrink SJ, Koçer A, Sack JT, Andersen OS (2014) Phytochemicals perturb membranes and promiscuously alter protein function. ACS Chem Biol 9:1788–1798PubMedPubMedCentralCrossRefGoogle Scholar
  59. Ivanovska N, Philipov S, Istatkova R, Georgieva P (1996) Antimicrobial and immunological activity of ethanol extracts and fractions from Isopyrum thalictroides. J Ethnopharmacol 54:143–151PubMedCrossRefGoogle Scholar
  60. Jaiswal R, Beuria TK, Mohan R, Mahajan SK, Panda D (2007) Totarol inhibits bacterial cytokinesis by perturbing the assembly dynamics of FtsZ. Biochemistry 46:4211–4220PubMedCrossRefGoogle Scholar
  61. Jin Dai, Mumper RJ (2010) Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules 15:7313–7352PubMedCrossRefGoogle Scholar
  62. Jones NL, Shabib S, Sherman PM (1997) Capsaicin as an inhibitor of the growth of the gastric pathogen Helicobacter pylori. FEMS Microbiol Lett 146:223–227PubMedCrossRefGoogle Scholar
  63. Kadota S, Basnet P, Ishii E, Tamura T, Namba T (1997) Antibacterial activity of trichorabdal A from Rabdosia trichocarpa against Helicobacter pylori. Zentralblatt Für Bakteriol Int J Med Microbiol 286:63–67CrossRefGoogle Scholar
  64. Kashman Y, Gustafson KR, Fuller RW, Cardellina JH, McMahon JB, Currens MJ, Buckheit RW, Hughes SH, Cragg GM, Boyd MR (1992) The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum. J Med Chem 35:2735–2743PubMedCrossRefGoogle Scholar
  65. Kaul TN, Middleton E, Ogra PL (1985) Antiviral effect of flavonoids on human viruses. J Med Virol 15:71–79PubMedCrossRefGoogle Scholar
  66. Kazmi MH, Malik A, Hameed S, Akhtar N, Noor Ali S (1994) An anthraquinone derivative from Cassia italica. Phytochemistry 36:761–763CrossRefGoogle Scholar
  67. Kim SH, Lee SJ, Lee JH, Sun WS, Kim JH (2002) Antimicrobial activity of 9-O-acyl- and 9-O-alkylberberrubine derivatives. Planta Med 68:277–281PubMedCrossRefGoogle Scholar
  68. Kinchington D, Kangro H, Jeffries KJ (1995) Design and testing of antiviral Compounds. In: Desselberger U (ed) Medical virology: a practical approach. Oxford University Press, New York, pp 147–171Google Scholar
  69. Kitagawa I, Mahmud T, Yokota K, Nakagawa S, Mayumi T, Kobayashi M, Shibuya H (1996) Indonesian medicinal plants. XVII. Characterization of quassinoids from the stems of Quassia indica. Chem Pharm Bull(Tokyo) 44:2009–2014CrossRefGoogle Scholar
  70. Knowles JR, Roller S, Murray DB, Naidu AS (2005) Antimicrobial action of carvacrol at different stages of dual-species biofilm development by Staphylococcus aureus and Salmonella enterica serovar Typhimurium. Appl Environ Microbiol 71:797–803PubMedPubMedCentralCrossRefGoogle Scholar
  71. Kothari V (2007) Pharmacologically active bioproducts. Biotech Books, New DelhiGoogle Scholar
  72. Kubo I, Muroi H, Himejima M (1992) Antibacterial activity of totarol and its potentiation. J Nat Prod 55:1436–1440PubMedCrossRefGoogle Scholar
  73. Kurokawa M, Basnet P, Ohsugi M, Hozumi T, Kadota S, Namba T, Kawana T, Shiraki K (1999) Anti-herpes simplex virus activity of moronic acid purified from Rhus javanica in vitro and in vivo. J Pharmacol Exp Ther 289:72–78PubMedGoogle Scholar
  74. Lai PK, Donovan J, Takayama H, Sakagami H, Tanaka A, Konno K, Nonoyama M (1990) Modification of human immunodeficiency viral replication by pine cone extracts. AIDS Res Hum Retroviruses 6:205–217PubMedCrossRefGoogle Scholar
  75. Li F, Goila-Gaur R, Salzwedel K, Kilgore NR, Reddick M, Matallana C, Castillo A, Zoumplis D, Martin DE, Orenstein JM, Allaway GP, Freed EO, Wild CT (2003) PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing. Proc Natl Acad Sci USA 100:13555–13560PubMedPubMedCentralCrossRefGoogle Scholar
  76. Liedtke MD, Rathbun RC (2009) Warfarin-antiretroviral interactions. Ann Pharmacother 43:322–328PubMedCrossRefGoogle Scholar
  77. Lis-Balchin M, Deans SG, Eaglesham E (1998) Relationship between bioactivity and chemical composition of commercial essential oils. Flavour Fragr J 13:98–104CrossRefGoogle Scholar
  78. Liu S, Lu H, Zhao Q, He Y, Niu J, Debnath AK, Wu S, Jiang S (2005) Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp 41. Biochim Biophys Acta 1723:270–281PubMedCrossRefGoogle Scholar
  79. Marino M, Bersani C, Comi G (1999) Antimicrobial activity of the essential oils of Thymus vulgaris L. measured using a bioimpedometric method. J Food Prot 62:1017–1023PubMedCrossRefGoogle Scholar
  80. Mazumder A, Raghavan K, Weinstein J, Kohn KW, Pommier Y (1995) Inhibition of human immunodeficiency virus type-1 integrase by curcumin. Biochem Pharmacol 49:1165–1170PubMedCrossRefGoogle Scholar
  81. McMahon JB, Currens MJ, Gulakowski RJ, Buckheit RW, Lackman-Smith C, Hallock YF, Boyd MR (1995) Michellamine B, a novel plant alkaloid, inhibits human immunodeficiency virus-induced cell killing by at least two distinct mechanisms. Antimicrob Agents Chemother 39:484–488PubMedPubMedCentralCrossRefGoogle Scholar
  82. Mendoza L, Wilkens M, Urzua A (1997) Antimicrobial study of the resinous exudates and of diterpenoids and flavonoids isolated from some Chilean Pseudognaphalium (Asteraceae). J Ethnopharmacol 58:85–88PubMedCrossRefGoogle Scholar
  83. Mishra KP, Sharma N, Diwake RD, Ganju L, Singh SB (2013) Plant derived antivirals: a potential source of drug development. J Virol Antivi Res 2:2Google Scholar
  84. Naik AD, Juvekar AR (2003) Effects of alkaloidal extract of Phyllanthus niruri on HIV replication. Indian J Med Sci 57:387–393PubMedGoogle Scholar
  85. Nakahara K, Kawabata S, Ono H, Ogura K, Tanaka T, Ooshima T, Hamada S (1993) Inhibitory effect of oolong tea polyphenols on glycosyl transferases of mutans Streptococci. Appl Environ Microbiol 59:968–973PubMedPubMedCentralGoogle Scholar
  86. Nakano M, Kurokawa M, Hozumi T, Saito A, Ida M, Morohashi M, Namba T, Kawana T, Shiraki K (1998) Suppression of recurrent genital herpes simplex virus type 2 infection by Rhus javanica in guinea pigs. Antiviral Res 39:25–33PubMedCrossRefGoogle Scholar
  87. Nazzaro F, Fratianni F, De Martino L, Coppola R, De Feo V (2013) Effect of essential oils on pathogenic bacteria. Pharmaceuticals (Basel) 6:1451–1474CrossRefGoogle Scholar
  88. Nostro A, Sudano Roccaro A, Bisignano G, Marino A, Cannatelli MA, Pizzimenti FC, Cioni PL, Procopio F, Blanco AR (2007) Effects of oregano, carvacrol and thymol on Staphylococcus aureus and Staphylococcus epidermidis biofilms. J Med Microbiol 56:519–523PubMedCrossRefGoogle Scholar
  89. Omulokoli E, Khan B, Chhabra SC (1997) Antiplasmodial activity of four Kenyan medicinal plants. J Ethnopharmacol 56:133–137PubMedCrossRefGoogle Scholar
  90. Paris A, Strukelj B, Renko M, Turk V, Pukl M, Umek A, Korant BD (1993) Inhibitory effect of carnosic acid on HIV-1 protease in cell-free assays [corrected]. J Nat Prod 56:1426–1430PubMedCrossRefGoogle Scholar
  91. Paulo L, Oleastro M, Gallardo E, Queiroz JA, Domingues F (2011) Anti-Helicobacter pylori and urease inhibitory activities of resveratrol and red wine. Food Res Int 44:964–969CrossRefGoogle Scholar
  92. Perrett S, Whitfield PJ, Sanderson L, Bartlett A (1995) The plant molluscicide Millettia thonningii (Leguminosae) as a topical antischistosomal agent. J Ethnopharmacol 47:49–54PubMedCrossRefGoogle Scholar
  93. Phillipson JD, O’Neill MJ (1987) New leads to the treatment of protozoal infections based on natural product molecules. Acta Pharm Nord 1:131–144Google Scholar
  94. Pyun MS, Shin S (2006) Antifungal effects of the volatile oils from Allium plants against Trichophyton species and synergism of the oils with ketaconazole. Phytomedicine 13:394–400PubMedCrossRefGoogle Scholar
  95. Rai D, Singh JK, Roy N, Panda D (2008) Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity. Biochem J 410:147–155PubMedCrossRefGoogle Scholar
  96. Rao KV, Sreeramulu K, Gunasekar D, Ramesh D (1993) Two new sesquiterpene lactones from Ceiba pentandra. J Nat Prod 56:2041–2045PubMedCrossRefGoogle Scholar
  97. Ravichandiran V, Shanmugam K, Anupama K, Thomas S, Princy A (2012) Structure-based virtual screening for plant-derived SdiA-selective ligands as potential antivirulent agents against uropathogenic Escherichia coli. Eur J Med Chem 48:200–205PubMedCrossRefGoogle Scholar
  98. Reichling J (1999) Plant–microbe interaction and secondary metabolites with antiviral, antibacterial and antifungal properties. In: Wink M (ed) Functions of plant secondary metabolites and their exploitation in biotechnology, Annual plant reviews, vol 3. Sheffield Academic Press, Sheffield, pp 187–273Google Scholar
  99. Ríos JL, Recio MC (2005) Medicinal plants and antimicrobial activity. J Ethnopharmacol 100:80–84PubMedCrossRefGoogle Scholar
  100. Sakanaka S, Kim M, Taniguchi M, Yamamoto T (1989) Antibacterial substances in japanese green tea extract against Streptococcus mutans, a cariogenic bacterium. Agric Biol Chem 53:2307–2311Google Scholar
  101. Sato M, Fujiwara S, Tsuchiya H, Fujii T, Iinuma M, Tosa H, Ohkawa Y (1996) Flavones with antibacterial activity against cariogenic bacteria. J Ethnopharmacol 54:171–176PubMedCrossRefGoogle Scholar
  102. Savoia D (2012) Plant derived antimicrobial compounds. Future Microbiol 7:979–990PubMedCrossRefGoogle Scholar
  103. Saxena S, Pant N, Jain DC, Bhakuni RS (2003) Antimalarial agents from plant sources. Curr Sci 85:1314–1329Google Scholar
  104. Scalbert A (1991) Antimicrobial properties of tannins. Phytochemistry 30:3875–3883CrossRefGoogle Scholar
  105. Schmidt B, Ribnicky DM, Poulev A, Logendra S, Cefalu WT, Raskin I (2008) A natural history of botanical therapeutics. Metabolism 57:S3–S9PubMedPubMedCentralCrossRefGoogle Scholar
  106. Shibata H, Kondo K, Katsuyama R, Kawazoe K, Sato Y, Murakami K, Takaishi Y, Arakaki N, Higuti T (2005) Alkyl gallates, intensifiers of beta-lactam susceptibility in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 49:549–555PubMedPubMedCentralCrossRefGoogle Scholar
  107. Shin S (2003) Anti-Aspergillus activities of plant essential oils and their combination effects with Ketoconazole or Amphotericin B. Arch Pharm Res 26:389–393PubMedCrossRefGoogle Scholar
  108. Shin S, Kang CA (2003) Antifungal activity of the essential oil of Agastache rugosa Kuntze and its synergism with ketaconazole. Lett Appl Microbiol 36:111–115PubMedCrossRefGoogle Scholar
  109. Stermitz FR, Lorenz P, Tawara JN, Zenewicz LA, Lewis K (2000) Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5′-methoxyhydnocarpin, a multidrug pump inhibitor. Proc Natl Acad Sci U S A 97:1433–1437PubMedPubMedCentralCrossRefGoogle Scholar
  110. Stern JL, Hagerman AE, Steinberg PD, Mason PK (1996) Phlorotannin-protein interactions. J Chem Ecol 22:1877–1899PubMedCrossRefGoogle Scholar
  111. Sun HD, Qiu SX, Lin LZ, Wang ZY, Lin ZW, Pengsuparp T, Pezzuto JM, Fong HH, Cordell GA, Farnsworth NR (1996) Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase. J Nat Prod 59:525–527PubMedCrossRefGoogle Scholar
  112. Suresh B, Sriram S, Dhanaraj SA, Elango K, Chinnaswamy K (1997) Anticandidal activity of Santolina chamaecyparissus volatile oil. J Ethnopharmacol 55:151–159PubMedCrossRefGoogle Scholar
  113. Tanaka H, Sato M, Fujiwara S, Hirata M, Etoh H, Takeuchi H (2002) Antibacterial activity of isoflavonoids isolated from Erythrina variegata against methicillin-resistant Staphylococcus aureus. Lett Appl Microbiol 35:494–498PubMedCrossRefGoogle Scholar
  114. Tassou C, Koutsoumanis K, Nychas GJE (2000) Inhibition of Salmonella enteritidis and Staphylococcus aureus in nutrient broth by mint essential oil. Food Res Int 33:273–280CrossRefGoogle Scholar
  115. Taylor RS, Edel F, Manandhar NP, Towers GH (1996) Antimicrobial activities of southern Nepalese medicinal plants. J Ethnopharmacol 50:97–102PubMedCrossRefGoogle Scholar
  116. Terras FRG, Schoofs HME, Thevissen K, Osborn RW, Vanderleyden J, Cammue BPA, Broekaert WF (1993) Synergistic enhancement of the antifungal activity of wheat and barley Thionins by radish and oilseed rape 2S albumins and by barley trypsin inhibitors. Plant Physiol 103:1311–1319PubMedPubMedCentralCrossRefGoogle Scholar
  117. Thornes RD (1997) Clinical and biological observations associated with coumarins. In: O’Kennedy R, Thornes RD (eds) Coumarins: biology, applications and mode of action. Wiley, New York, p 256Google Scholar
  118. Tsuchiya H, Sato M, Miyazaki T, Fujiwara S, Tanigaki S, Ohyama M, Tanaka T, Iinuma M (1996) Comparative study on the antibacterial activity of phytochemical flavanones against methicillin-resistant Staphylococcus aureus. J Ethnopharmacol 50:27–34PubMedCrossRefGoogle Scholar
  119. Vijaya K, Ananthan S, Nalini R (1995) Antibacterial effect of theaflavin, polyphenon 60 (Camellia sinensis) and Euphorbia hirta on Shigella spp. a cell culture study. J Ethnopharmacol 49:115–118PubMedCrossRefGoogle Scholar
  120. Vishwakarma RA (2004) Stereoselective Synthesis of α-Arteether from Artemisinin. J Nat Prod 53:216–217CrossRefGoogle Scholar
  121. Watanbe H, Miyaji C, Makino M, Abo T (1996) Therapeutic effects of glycyrrhizin in mice infected with LP-BM5 murine retrovirus and mechanisms involved in the prevention of disease progression. Biotherapy (Dordrecht, Netherlands) 9:209–220CrossRefGoogle Scholar
  122. Weenen H, Nkunya MH, Bray DH, Mwasumbi LB, Kinabo LS, Kilimali VA, Wijnberg JB (1990) Antimalarial compounds containing an alpha, beta-unsaturated carbonyl moiety from Tanzanian medicinal plants. Planta Med 56:371–373PubMedCrossRefGoogle Scholar
  123. Yao XJ, Wainberg MA, Parniak MA (1992) Mechanism of inhibition of HIV-1 infection in vitro by purified extract of Prunella vulgaris. Virology 187:56–62PubMedCrossRefGoogle Scholar
  124. White NJ (1997) Assessment of the pharmacodynamic properties of antimalarial drugs in vivo. Antimicrob Agents Chemother 41(7):1413–1422Google Scholar
  125. Yi ZB, Yan Y, Liang YZ, Bao Z (2007) Evaluation of the antimicrobial mode of berberine by LC/ESI-MS combined with principal component analysis. J Pharm Biomed Anal 44:301–304PubMedCrossRefGoogle Scholar
  126. Zhang Y, Lewis K (1997) Fabatins: new antimicrobial plant peptides. FEMS Microbiol Lett 149:59–64PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  • Reshma Reghu
    • 1
  • Pramod Sahadevan
    • 2
  • Shiburaj Sugathan
    • 1
  1. 1.Division of MicrobiologyJawaharlal Nehru Tropical Botanic Garden and Research InstituteThiruvananthapuramIndia
  2. 2.Department of BiochemistryMontreal Heart InstituteQuébecCanada

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