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Immune Checkpoint Blockade and Gastric Cancer

  • Shu Su
  • Baorui Liu
Chapter

Abstract

The term “checkpoints” refers to a broad spectrum of either co-receptors or ligands that are widely expressed by immune cells. Importantly, such checkpoints regulate immune cells’ activation. The “inhibitory checkpoints” represent those molecules that play an important role in preventing over-activation of the immune system and are important to maintaining self-tolerance. In this way, immune attack by the host immune system can be prevented. Conversely and in the context of the tumor-immune environment, co-inhibitory receptors may pose a threat to the host’s health by preventing an immune response against these malignancies. Both co-inhibitory receptors and ligands are highly expressed in a large number of malignancies. This high expression allows for successful evasion of antitumor immune responses. One of the most promising tumor immunotherapy strategies is to interrupt these immune “brakes” by blocking antibodies that prevent interactions between receptors and their cognate ligands. As shown by recent clinical trials targeting either the PD-1/PD-L1 or CTLA-4, pathways has yielded exciting results. However, there remains very limited study and understanding on gastric cancer when compared to other malignancies such as melanoma or lung cancer.

Keywords

Gastric Cancer Gastric Cancer Patient Gastric Cancer Tissue Immune Checkpoint Immune Inhibitory Checkpoint 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  • Shu Su
    • 1
  • Baorui Liu
    • 1
  1. 1.The Comprehensive Cancer Centre of Drum Tower HospitalMedical School of Nanjing University and Clinical Cancer Institute of Nanjing UniversityNanjingChina

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