Potentials of Cord Blood Use in Transfusion Medicine

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Abstract

Cord blood could prove to be the perfect choice for patients with severe anemia of different indications where blood transfusion is required, after it is screened for transfusion-transmitted infection. The reason for this suggestion lies in the fact that cord blood contains a plentiful mix of fetal and adult hemoglobin, has high WBC and platelet counts, and has a hypoantigenic nature apart from a different metabolic profile with inflammatory and noninflammatory cytokine support and an increased intrinsic affinity for oxygen.

Keywords

Cord blood Fetal hemoglobin Hematopoiesis Immunomodulation Transfusion 

Abbreviations

HbA

Hemoglobin A

HbF

Hemoglobin F (fetal)

HLA

Human leukocyte antigen

M-CSF

Macrophage colony-stimulating factor

MSCs

Mesenchymal stem cells

SSEA

Stage-specific embryonic antigen

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Notes

Acknowledgments

The author gratefully acknowledges the guidance and material support, including permission and developing infrastructure, of the Department of Health and Family Welfare, Government of West Bengal. The author is also grateful to the patients who consented to participate in the study. The author followed the ICMR guidelines with its periodic upgradation and also the suggestions of the Institutional Ethics Committee headed by Prof. M.K. Chettri D.Sc., M.D., F.R.C.P. Prof. Kanailal Mukherjee, M.B.B.S., Ph.D. (Wisconsin), monitored the animal experimental protocol as per the CPCSEA (Committee for the Purpose of Control and Supervision of Experiments on Animals) which preceded the use of cord blood in humans.

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© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Department of Regenerative Medicine and Translational ScienceCalcutta School of Tropical MedicineKolkataIndia

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