Heterogeneous Platinum Metal Catalyzed Deuterium Generation and Labeling Methods Using Hydrogen Gas and Deuterium Oxide as Key Reagents

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Abstract

Deuterium (heavy hydrogen, D or 2H), a stable isotope of hydrogen (1H) consists of one proton, one neutron and one electron and used extensively in a wide range of fields including science, chemistry, medicine, etc. We have developed quite simple and post-synthetic D labeled methods using a combination of platinum metal on carbon and deuterium oxide (D2O) as the catalyst and a D source in the presence of organic substrates, and a highly pure D2 gas preparation method occurred at room temperature (rt) via the catalytic H2–D2 exchange reaction between the H atom of the H2 gas with the D atom of D2O without any substrates. This review illustrates and describes such straightforward and useful methodologies.

Keywords

Deuterium labeling H–D exchange C–H activation Platinum-group metal on carbon Deuterium gas preparation Deuterium oxide Hydrogen gas 
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© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Laboratory of Organic ChemistryGifu Pharmaceutical UniversityGifuJapan

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