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Developing Stress-Tolerant Plants by Manipulating Components Involved in Oxidative Stress

  • Shweta SharmaEmail author
  • Usha Kiran
  • Sudhir Kumar Sopory
Chapter

Abstract

Oxidative stress is one of the crucial outcomes of biotic and abiotic stress which leads to the physiological and metabolic alterations in plant system and, therefore, requires a balanced control of reactive oxygen species (ROS) production and its scavenging through antioxidative enzymes and proteins. The enzymatic components of antioxidative defense system consist of several enzymes including catalase (CAT), superoxide dismutase (SOD), and guaiacol peroxidase (GPX) and also the enzymes of ascorbate-glutathione (AsA-GSH) cycle, i.e., ascorbate peroxidase (APX), dehydroascorbate reductase (DHAR), monodehydroascorbate reductase (MDHAR), and glutathione reductase (GR). The nonenzymatic components include ascorbate (AsA) and glutathione (GSH) along with carotenoids and tocopherols along with other phenolic compounds. Exploiting the antioxidative behavior of these enzymes, several plants have been modified using transgenic techniques overexpressing the components of antioxidative stress pathways. Moreover, there are several other redox proteins, which have been genetically engineered to help plant survive in adverse conditions. This suggests that the development of transgenic plants overexpressing enzymes and redox-sensitive proteins associated with oxidative stress and antioxidative stress pathways will surely provide an important link of their role in tolerance to oxidative damage in crops. This chapter elucidates the recent advances in the defense system of plants during oxidative stress and also discusses the potential strategies for enhancing tolerance to oxidative stress.

Keywords

Reactive Oxygen Species Transgenic Plant Salt Stress Reactive Oxygen Species Production Glutathione Reductase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Authors thank the International Centre for Genetic Engineering and Biotechnology (ICGEB), India, and the Department of Biotechnology (DBT), Government of India, for providing facilities. The project fellowship award to Usha Kiran under UGC Major Project is gratefully acknowledged.

References

  1. Alia PS, Mohanty P (1997) Involvement of proline in protecting thylakoid membranes against free radical-induced photodamage. J Photochem Photobiol 38:253–257CrossRefGoogle Scholar
  2. Allen RD, Webb RP, Schake SA (1997) Use of transgenic plants to study antioxidant defenses. Free Radic Biol Med 23:473–479CrossRefPubMedGoogle Scholar
  3. Alscher RG, Donahue JL, Cramer CL (1997) Reactive oxygen species and antioxidants: relationships in green cells. Physiol Plant 100:224–233CrossRefGoogle Scholar
  4. Aono M, Kubo A, Saji H et al (1993) Enhanced tolerance to photo-oxidative stress in transgenic Nicotiana tabacum with high chloroplastic glutathione reductase activity. Plant Cell Physiol 34:129–135Google Scholar
  5. Asada K (1992) Ascorbate peroxidase-a hydrogen peroxide scavenging enzyme in plants. Physiol Plant 85:235–241CrossRefGoogle Scholar
  6. Asada K (2006) Production and scavenging of reactive oxygen species in chloroplasts and their functions. Plant Physiol 141:391–396CrossRefPubMedPubMedCentralGoogle Scholar
  7. Badawi GH, Yamauchi Y, Shimada E, Sasaki R, Kawano N, Tanaka K (2004) Enhanced tolerance to salt stress and water deficit by overexpressing superoxide dismutase in tobacco (Nicotiana tabacum) chloroplasts. Plant Sci 66:919–928CrossRefGoogle Scholar
  8. Baker A, Graham I (2002) Plant peroxisomes. biochemistry, cell biology and biotechnological applications. Kluwer Academic Publishers, Dordrecht, pp. 1–17Google Scholar
  9. Bhattacharjee S (2005) Reactive oxygen species and oxidative burst: roles in stress, senescence and signal transduction in plants. Curr Sci 89:1113–1121Google Scholar
  10. Bhattacharjee S (2012) The language of reactive oxygen species signaling in plants. J Bot 985298, 22 pagesGoogle Scholar
  11. Bowler C, Slooten L, Vandenbranden S et al (1991) Manganese superoxide dismutase can reduce cellular damage mediated by oxygen radicals in transgenic plants. EMBO J 10:1723–1732PubMedPubMedCentralGoogle Scholar
  12. Brooker RJ (2011) Genetics: analysis and principles, 4th edn. McGraw-Hill Science, LondonGoogle Scholar
  13. Castillo C, Hernandez J, Bravo A et al (2005) Oxidative status during late pregnancy and early lactation in dairy cows. Vet J 169:286–292CrossRefPubMedGoogle Scholar
  14. Chen C, Dickman MB (2005) Proline suppresses apoptosis in the fungal pathogen Colletotrichum trifolii. Proc Natl Acad Sci U S A 102:3459–3464CrossRefPubMedPubMedCentralGoogle Scholar
  15. Chen X, Oh SW, Zheng Z, Chen HW, Shin H, Hou SX (2003) Cyclin d-cdk4 and cyclin e-cdk2 regulate the Jak/STAT signal transduction pathway in Drosophila. Dev Cell 2:179–190CrossRefGoogle Scholar
  16. Creissen GP, Edwards A, Mullineaux PM (1994) Glutathione reductase and ascorbate peroxidase. CRC Press, Boca Raton, pp. 343–364Google Scholar
  17. del Rio LA, Corpas FJ, Sandalio LM et al (2002) Reactive oxygen species, antioxidant systems and nitric oxide in peroxisomes. J Exp Bot 53:1255–1272CrossRefPubMedGoogle Scholar
  18. del Río LA, Sandalio LM, Corpas FJ, Palma MJ, Barroso JB (2006) Reactive oxygen species and reactive nitrogen species in peroxisomes: production, scavenging, and role in cell signaling. Plant Physiol 141:330–335Google Scholar
  19. Desikan R, Clarke A, Hancock JT et al (1999) H2O2 activates a MAP kinase-like enzyme in Arabidopsis thaliana suspension cultures. J Exp Bot 50:1863–1866Google Scholar
  20. Desikan R, Neill SJ, Hancock JT (2000) Hydrogen peroxide-induced gene expression in Arabidopsis thaliana. Free Radic Biol Med 28(773):778Google Scholar
  21. Devasagayam TPA, Tilak JC, Boloor KK et al (2004) Free radicals and antioxidants in human health: current status and future prospects. JAPI 52:796Google Scholar
  22. Foyer C (1997) Oxygen metabolism and electron transport in photosynthesis in the molecular biology of free radical scavenging systems. J Scandalios 502:587–621Google Scholar
  23. Foyer CH, Noctor G (2003) Redox sensing and signalling associated with reactive oxygen in chloroplasts, peroxisomes and mitochondria. Physiol Plant 119:355–364CrossRefGoogle Scholar
  24. Foyer CH, Noctor G (2005a) Oxidant and antioxidant signalling in plants: a re-evaluation of the concept of oxidative stress in a physiological context. Plant Cell Environ 28:1056–1071CrossRefGoogle Scholar
  25. Foyer CH, Noctor G (2005b) Redox homeostasis and antioxidant signaling: a metabolic interface between stress perception and physiological responses. Plant Cell 17:1866–1875CrossRefPubMedPubMedCentralGoogle Scholar
  26. Foyer CH, Noctor G (2009) Redox regulation in photosynthetic organisms: signaling, acclimation, and practical implications. Antioxid Redox Signal 11:861–905CrossRefPubMedGoogle Scholar
  27. Foyer CH, Lelandais M, Galap C, Kunert KJ (1991) Effects of elevated cytosolic glutathione reductase activity on the cellular glutathione pool and photosynthesis in leaves under normal and stress conditions. Plant Physiol 97:863–872CrossRefPubMedPubMedCentralGoogle Scholar
  28. Foyer CH, Descourvières P, Kunert KJ (1994) Protection against oxygen radicals: an important defence mechanism studied in transgenic plants. Plant Cell Environ 17:507–523CrossRefGoogle Scholar
  29. Gupta AS, Webb RP, Holaday AS et al (1993) Overexpression of superoxide dismutase protects plants from oxidative stress (induction of ascorbate peroxidase in superoxide dismutase- overexpressing plants. Plant Physiol 103:1067–1073Google Scholar
  30. Halliwell B (2006) Reactive species and antioxidants: redox biology is a fundamental theme of aerobic life. Plant Physiol 141:312–322CrossRefPubMedPubMedCentralGoogle Scholar
  31. Halliwell B, Gutteridge JMC (1999) Free radicals in biology and medicine, 3rd edn. Clarendon Press, OxfordGoogle Scholar
  32. Heine GF, Hernandez JM, Grotewold E (2004) Two cysteines in plant R2R3 MYB domains participate in REDOX-dependent DNA binding. J Biol Chem 279:37878–37885CrossRefPubMedGoogle Scholar
  33. Hensley K, Robinson KA, Gabbita SP et al (2000) Reactive oxygen species, cell signaling, and cell injury. Free Radic Biol Med 28:1456–1462CrossRefPubMedGoogle Scholar
  34. Hoque MA et al (2008) Proline and glycinebetaine enhance antioxidant defense and methylglyoxal detoxification systems and reduce NaCl-induced damage in cultured tobacco cells. J Plant Physiol 165:813–824CrossRefPubMedGoogle Scholar
  35. Husaini AM, Abdin MZ (2008) Development of transgenic strawberry (Fragaria x ananassa Duch.) plants tolerant to salt stress. Plant Sci 174:446–455CrossRefGoogle Scholar
  36. Indorf M, Cordero J, Neuhaus G, Rodríguez-Franco M (2007) Salt tolerance (STO), a stress-related protein, has a major role in light signalling. Plant J 51:563–574CrossRefPubMedGoogle Scholar
  37. Iqbal M, Ashraf M (2007) Seed treatment with auxins modulates growth and ion partitioning in salt-stressed wheat plants. J Integr Plant Biol 49:1045–1057CrossRefGoogle Scholar
  38. Islam MM et al (2009) Exogenous proline and glycinebetaine increase antioxidant enzyme activities and confer tolerance to cadmium stress in cultured tobacco cells. J Plant Physiol 166:1587–1597CrossRefPubMedGoogle Scholar
  39. Jones DP (2006) Redefining oxidative stress. Antioxid Redox Signal 8:1865–1879CrossRefPubMedGoogle Scholar
  40. Karpinski S, Escobar C, Karpinska B et al (1997) Photosynthetic electron transport regulates the expression of cytosolic ascorbate peroxidase genes in arabidopsis during excess light stress. Plant Cell 9:627–640CrossRefPubMedPubMedCentralGoogle Scholar
  41. Khedr AH et al (2003) Proline induces the expression of salt-stress-responsive proteins and may improve the adaptation of Pancratium maritimum L. to salt-stress. J Exp Bot 54:2553–2562CrossRefPubMedGoogle Scholar
  42. Kocsy G, Laurie R, Szalai G, Szilagyi V, Simon-Sarkadi L, Galiba G, De Ronde JA (2005) Genetic manipulation of proline levels affects antioxidants in soybean subjected to simultaneous drought and heat stresses. Physiol Plant 124:227–235CrossRefGoogle Scholar
  43. Konstantinos PA, Imene T, Panagiotis MN, Roubelakis-Angelakis KA (2010) ABA-dependent amine oxidase-derived H2O2 affects stomata conductance. Plant Signal Behav 5:1153–1156CrossRefPubMedPubMedCentralGoogle Scholar
  44. Kovalchuk I (2010) Multiple roles of radicles in plants in reactive oxygen species and antioxidants in higher plants. CRC Press, New York, pp. 31–44CrossRefGoogle Scholar
  45. Kwon SY, Jeong YJ, Lee HS et al (2002) Enhanced tolerances of transgenic tobacco plants expressing both superoxide dismutase and ascorbate peroxidase in chloroplasts against methyl viologen-mediated oxidative stress. Plant Cell Environ 25:873–882CrossRefGoogle Scholar
  46. Kwon SY, Choi SM, Ahn YO et al (2003) Enhanced stress-tolerance of transgenic tobacco plants expressing a human DHAR gene. J Plant Physiol 160:347–353CrossRefPubMedGoogle Scholar
  47. Lee SH, Ahsan N, Lee KW et al (2007) Simultaneous overexpression of both CuZn superoxide dismutase and ascorbate peroxidase in transgenic tall fescue plants confers increased tolerance to a wide range of abiotic stresses. J Plant Physiol 164:1626–1638CrossRefPubMedGoogle Scholar
  48. Levine A, Tenhaken R, Dixon R et al (1994) H2O2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response. Cell 79:583–593CrossRefPubMedGoogle Scholar
  49. Lin KC, Sun PC, Lin PL (2011) Production of reactive oxygen species and induction of signaling pathways for the ACO gene expressions in tomato plants triggered by the volatile organic compound ether. Plant Cell Rep 30:599–611CrossRefPubMedGoogle Scholar
  50. Lopez-Delgado H, Dat JF, Foyer CH et al (1998) Induction of thermotolerance in potato microplants by acetylsalicylic acid and H2O2. J Exp Bot 49:713–720CrossRefGoogle Scholar
  51. Mahalingam R, Fedoroff N (2003) Stress response, cell death and signalling: the many faces of reactive oxygen species. Physiol Plant 119:56–68CrossRefGoogle Scholar
  52. Matsuda Y, Okuda T, Sagisaka S (1994) Regulation of protein synthesis by hydrogen peroxide in crowns of winter wheat. Biosci Biotechnol Biochem 58(5):906–909CrossRefGoogle Scholar
  53. Matysik J, Alia BB, Mohanty P (2002) Molecular mechanism of quenching of reactive oxygen species by proline under stress in plants. Curr Sci 82:525–532Google Scholar
  54. McKersie BD, Chen Y, De Beus M et al (1993) Superoxide dismutase enhances tolerance of freezing stress in transgenic alfalfa (Medicago sativa L.). Plant Physiol 103:1155–1163CrossRefPubMedPubMedCentralGoogle Scholar
  55. McKersie BD, Bowley SR, Harjanto E, Leprince O (1996) Water-deficit tolerance and field performance of transgenic alfalfa overexpressing superoxide dismutase. Plant Physiol 111:1177–1181CrossRefPubMedPubMedCentralGoogle Scholar
  56. McKersie BD, Murnaghan J, Jones KS, Bowley SR (2000) Iron-superoxide dismutase expression in transgenic alfalfa increases winter survival without a detectable increase in photosynthetic oxidative stress tolerance. Plant Physiol 122:1427–1438CrossRefPubMedPubMedCentralGoogle Scholar
  57. Mehdy MC (1994) Active oxygen species in plant defense against pathogens. Plant Physiol 105:467–472CrossRefPubMedPubMedCentralGoogle Scholar
  58. Mehta SK, Gaur JP (1999) Heavy-metal–induced proline accumulation and its role in ameliorating metal toxicity in Chlorella vulgaris. New Phytol 143:253–259CrossRefGoogle Scholar
  59. Miranda ML, Wang Z, Daniel EO, Xianghui R, Ernest FT, Larry JY (2004) Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene. Nature 429:754–757CrossRefGoogle Scholar
  60. Mittler R, Vanderauwera S, Gollery M et al (2004) Reactive oxygen gene network of plants. Trends Plant Sci 9:1360–1385CrossRefGoogle Scholar
  61. Mylona PV, Polidoros AN (2010) ROS regulation and antioxidant genes in reactive oxygen species and antioxidants in higher plants. CRC Press:1–30Google Scholar
  62. Nishiyama A, Masutani H, Nakamura H et al (2001) Redox regulation by thioredoxin and thioredoxinbinding proteins. IUBMB Life 52:29–33CrossRefPubMedGoogle Scholar
  63. Noctor G, Foyer CH (1998) ASCORBATE AND GLUTATHIONE: keeping active oxygen under control Annu Rev Plant Physiol Plant Mol Biol. 49:249–279Google Scholar
  64. Noctor G, Veljovic-Jovanovic SD, Driscoll S, Novitskaya L, Foyer CH (2002) Drought and oxidative load in the leaves of C3 plants: a predominant role for photorespiration? Ann Bot (Lond) 89:841–850CrossRefGoogle Scholar
  65. Nounjan N, Theerakulpisut P (2012) Effects of exogenous proline and trehalose on physiological responses in rice seedlings during salt-stress and after recovery. Plant Soil Environ 58:309–315CrossRefGoogle Scholar
  66. Overmyer K, Brosché M, Pellinen R, Kuittinen T, Tuominen H, Ahlfors R, Keinänen M, Saarma M, Scheel D, Kangasjärvi J (2005) Ozone-induced programmed cell death in the Arabidopsis radical-induced cell death1 mutant. Plant Physiol 137:1092–1104CrossRefPubMedPubMedCentralGoogle Scholar
  67. Payton P, Allen RD, Trolinder N et al (1997) Over-expression of chloroplast-targeted Mn superoxide dismutase in cotton of chloroplast-targeted Mn superoxide dismutase in cotton tion of photosynthesis after short exposures to low temperature and high light intensity. Photosynth Res 52:233–244CrossRefGoogle Scholar
  68. Perl A, Perl-Treves R, Dalili S (1993) Enhanced oxidative stress defence in transgenic potato expressing Cu/Zn superoxide dismutase. Theor Appl Genet 85:568–576CrossRefPubMedGoogle Scholar
  69. Pignocchi C, Foyer CH (2003) Apoplastic ascorbate metabolism and its role in the regulation of cell signalling. Curr Opin Plant Biol 6:379–389CrossRefPubMedGoogle Scholar
  70. Pinto AP, Mota AM, de Varennes A, Pinto FC (2004) Influence of organic matter on the uptake of cadmium, zinc, copper and iron by sorghum plants. Sci Tot Environ 326:239–247CrossRefGoogle Scholar
  71. Pitcher LH, Repetti P, Zilinskas BA (1994) Overproduction of ascorbate peroxidase protects transgenic tobacco plants against oxidative stress. Plant Physiol 105:159–169CrossRefGoogle Scholar
  72. Prasad TK, Anderson MD, Stewart CR (1995) Localization and characterization of peroxidases in the mitochondria of chilling-acclimated maize seedlings. Plant Physiol 108:1597–1605CrossRefPubMedPubMedCentralGoogle Scholar
  73. Prashanth SR, Sadhasivam V, Parida A (2008) Over expression of cytosolic copper/zinc superoxide dismutase from a mangrove plant Avicennia marina in indica rice var Pusa Basmati-1 confers abiotic stress tolerance. Transgenic Res 17:281–291CrossRefPubMedGoogle Scholar
  74. Rhoads DM, Umbach AL, Subbaiah CC et al (2006) Mitochondrial reactive oxygen species. Contribution to oxidative stress and interorganellar signaling. Plant Physiol 141:357–366CrossRefPubMedPubMedCentralGoogle Scholar
  75. Romero-Puertas MC, Rodríguez-Serrano M, Corpas FJ, Gómez M, del Río LA, Sandalio LM (2004) Cd-induced subcellular accumulation of O2.− and H2O2 in pea leaves. Plant Cell Environ 27:1122–1134CrossRefGoogle Scholar
  76. Rouhier N, Lemaire SD, Jacquot JP (2008) The role of glutathione in photosynthetic organisms: emerging functions for glutaredoxins and glutathionylation. Annu Rev Plant Biol 59:143–166CrossRefPubMedGoogle Scholar
  77. Santos M, Gousseau H, Lister C et al (1996) Cytosolic ascorbate peroxidase from Arabidopsis thaliana L. is encoded by a small multigene family. Planta 198:64–69CrossRefPubMedGoogle Scholar
  78. Semchuk NM, Lushchak OV, Falk J et al (2009) Inactivation of gene encoding tocopherol biosynthetic pathway enzymes result in oxidative stress in outdoor grown Arabidopsis thaliana. Plant Physiol Biochem 47:384–390CrossRefPubMedGoogle Scholar
  79. Sen Gupta A, Heinen JL, Holaday AS et al (1993) Increased resistance in transgenic plants that overexpress chloro plastic Cu/Zn superoxide dismutase. Proc Natl Acad Sci U S A 90:1629–1633CrossRefGoogle Scholar
  80. Serpa V, Vernal J, Lamattina L et al (2007) Inhibition of AtMYB2 DNA-binding by nitric oxide involves cysteine S-nitrosylation. Biochem Biophys Res Commun 361:1048–1053CrossRefPubMedGoogle Scholar
  81. Shaikhali J, Heiber I, Seidel T et al (2008) The redox- sensitive transcription factor Rap2.4a controls nuclear expression of 2-Cys peroxiredoxin A and other chloroplast antioxidant enzymes. BMC Plant Biol 8:1178–1186CrossRefGoogle Scholar
  82. Shaikhali J, Noren L, De Dios Barajas-Lopez J et al (2012) Redox-mediated mechanisms regulate DNA binding activity of the G-group of basic region leucine zipper (bZIP) transcription factors in Arabidopsis. J Biol Chem 287:27510–27525CrossRefPubMedPubMedCentralGoogle Scholar
  83. Sharma P, Jha AB, Dubey RS et al (2012) Reactive oxygen species, oxidative damage, and antioxidative defense mechanism in plants under stressful conditions. J Bot 2012:1–26 Hindawi Publishing CorporationCrossRefGoogle Scholar
  84. Sharma S, Kaur C, Singla-Pareek SL, Sopory SK (2016) OsSRO1a interacts with RNA binding domain-containing protein (OsRBD1) and functions in abiotic stress tolerance in yeast. Front Plant Sci 7:62PubMedPubMedCentralGoogle Scholar
  85. Sharma V, Sharma A, Kansal L (2010) The effect of oral administration of Allium sativum extracts on lead nitrate induced toxicity in male mice. Food Chem Toxicol 48:928–936CrossRefPubMedGoogle Scholar
  86. Sharma S, Villamor JG, Verslues PE (2011) Essential role of tissue-specific proline synthesis and catabolism in growth and redox balance at low water potential. Plant Physiol 157:292–304CrossRefPubMedPubMedCentralGoogle Scholar
  87. Singh-Gill S, Tuteja N (2010) Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants Plant Physiol. Biochemist 48:909–930Google Scholar
  88. Smirnoff N, Cumbes QJ (1989) Hydroxyl radical scavenging activity of complete solutes. Phytochemistry 28:1057–1060CrossRefGoogle Scholar
  89. Suzuki N, Koussevitzky S, Mittler R et al (2012) ROS and redox signaling in the response of plants to abiotic stress. Plant Cell Environ 35:259–270CrossRefPubMedGoogle Scholar
  90. Szekely G, Abraham E, Cselo A et al (2008) Duplicated P5CS genes of Arabidopsis play distinct roles in stress regulation and developmental control of proline biosynthesis. Plant J 53:11–28CrossRefPubMedGoogle Scholar
  91. Tanaka K, Kondo N, Sugahara K (1982) Accumulation of hydrogen peroxide in chloroplast of SO2-fumigated spinach leaves. Plant Cell Physiol 23:999–1007CrossRefGoogle Scholar
  92. Tang L, Kwon SY, Kim SH et al (2006) Enhanced tolerance of transgenic potato plants expressing both superoxide dismutase and ascorbate peroxidase in chloroplasts against oxidative stress and high temperature. Plant Cell Rep 25:1380–1386CrossRefPubMedGoogle Scholar
  93. Tayefi-Nasrabadi H, Dehghan G, Daeihassani B et al (2011) Some biochemical properties of guaiacol peroxidases as modified by salt stress in leaves of salt-tolerant and salt-sensitive safflower (Carthamus tinctorius L.cv.) cultivars. Afr J Biotech 10:751–763Google Scholar
  94. Tepperman JM, Dunsmuir P (1990) Transformed plants with elevated levels of chloroplastic SOD are not more resistant to superoxide toxicity. Plant Mol Biol 14:501–511CrossRefPubMedGoogle Scholar
  95. Trolinder NL, Allen RD (1994) Expression of chloroplast localized Mn SOD in transgenic cotton. J Cell Biochem 18:97Google Scholar
  96. Tron AE, Bertoncini CW, Chan RL et al (2002) Redox regulation of plant homeodomain transcription factors. J Biol Chem 277:34800–34807CrossRefPubMedGoogle Scholar
  97. Urban P et al (1997) Cloning, yeast expression, and characterization of the coupling of two distantly related Arabidopsis thaliana NADPH-cytochrome P450 reductases with P450 CYP73A5. J Biol Chem 272:19176–19186CrossRefPubMedGoogle Scholar
  98. Van Camp W, Willekens H, Bowler C et al (1994) Elevated levels of superoxide dismutase protect transgenic plants against ozone damage. Nat Biotechnol 12:165–168CrossRefGoogle Scholar
  99. Van Camp W, Capiau K, Van Montagu M, Inzé D, Slooten L (1996) Enhancement of oxidative stress tolerance in transgenic tobacco plants overexpressing Fe-superoxide dismutase in chloroplasts. Plant Physiol 112:1703–1714CrossRefPubMedPubMedCentralGoogle Scholar
  100. Wagner AM, Krab K (1995) The alternative respiration pathway in plants: Role and regulation. Physiol Plant 95:318–325CrossRefGoogle Scholar
  101. Wang J, Zhang H, Allan RD (1999) Overexpression of an Arabidopsis peroxisomal ascorbate peroxidase gene in tobacco increases protection against oxidative stress. Plant Cell Physiol 40:725–732CrossRefPubMedGoogle Scholar
  102. Zhou C, Huang Y, Przedborski S (2008) Oxidative stress in parkinson’s disease: A mechanism of pathogenic and therapeutic significance. Ann N Y Acad Sci 1147:93–104CrossRefPubMedPubMedCentralGoogle Scholar

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© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  • Shweta Sharma
    • 1
    Email author
  • Usha Kiran
    • 2
  • Sudhir Kumar Sopory
    • 1
  1. 1.Plant Molecular Biology GroupInternational Centre for Genetic Engineering and BiotechnologyNew DelhiIndia
  2. 2.CTPD, Department of BiotechnologyJamia HamdardNew DelhiIndia

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