Early Diagnosis of Pancreatic Cancer Using Endoscopic Ultrasound

  • Susumu HijiokaEmail author
  • Kenji Yamao
  • Nobumasa Mizuno
  • Hiroshi Imaoka
  • Vikram Bhatia
  • Kazuo Hara


Despite a low incidence, the mortality rate of pancreatic cancer (PC) is high. Early detection and optimal treatment based on the findings of various imaging modalities are essential to improve the survival rate of patients with PC. Multi-detector (MD) row computed tomography (CT) is currently the standard imaging modality for evaluating PC worldwide. However, 10% of PC tumors can be iso-attenuated on CT and thus invisible, especially when ≤2 cm. Endoscopic ultrasonography (EUS) can detect tumors that are <10 cm at a higher rate than CT and might be useful for diagnosing high-grade pancreatic intraepithelial neoplasia (PanIN3) as well as magnetic resonance cholangiopancreatography, as they can both detect local irregular stenosis of the pancreatic duct.

Population-based screening is not feasible due to the low incidence of PC, but it is advisable for high-risk patients, in whom premalignant lesions can be detected using EUS.

The introduction of recent novel techniques such as contrast-enhanced EUS and elastography might improve the accuracy of EUS.

We reviewed the role of EUS in the detection and diagnosis of early-stage PC.


Endoscopic ultrasound Carcinoma in situ of pancreatic cancer Early diagnosis for pancreatic cancer 


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Copyright information

© Springer Science+Business Media Singapore 2017

Authors and Affiliations

  • Susumu Hijioka
    • 1
    Email author
  • Kenji Yamao
    • 1
  • Nobumasa Mizuno
    • 1
  • Hiroshi Imaoka
    • 1
  • Vikram Bhatia
    • 2
  • Kazuo Hara
    • 1
  1. 1.Department of GastroenterologyAichi Cancer Center HospitalNagoyaJapan
  2. 2.Department of GastroenterologyFortis Escorts HospitalNew DelhiIndia

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