Bayesian Computation Methods for Inferring Regulatory Network Models Using Biomedical Data

Chapter
First Online:
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 939)

Abstract

The rapid advancement of high-throughput technologies provides huge amounts of information for gene expression and protein activity in the genome-wide scale. The availability of genomics, transcriptomics, proteomics, and metabolomics dataset gives an unprecedented opportunity to study detailed molecular regulations that is very important to precision medicine. However, it is still a significant challenge to design effective and efficient method to infer the network structure and dynamic property of regulatory networks. In recent years a number of computing methods have been designed to explore the regulatory mechanisms as well as estimate unknown model parameters. Among them, the Bayesian inference method can combine both prior knowledge and experimental data to generate updated information regarding the regulatory mechanisms. This chapter gives a brief review for Bayesian statistical methods that are used to infer the network structure and estimate model parameters based on experimental data.

Keywords

Bayesian inference Approximate Bayesian computation Genetic regulation Reverse engineering 
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Copyright information

© Springer Science+Business Media Singapore 2016

Authors and Affiliations

  1. 1.School of Mathematical ScienceMonash UniversityClaytonAustralia

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