Telocytes pp 77-103 | Cite as

Telocytes: New Players in Gallstone Disease

  • Artur Pasternak
  • Krzysztof Gil
  • Andrzej Matyja
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 913)


Cholesterol gallstone disease is highly prevalent in Western countries, particularly in women and some specific ethnic groups. The mechanisms behind the formation of gallstones are not clearly understood, but gallbladder dysmotility seems to be a key factor that triggers the precipitation of cholesterol microcrystals from supersaturated lithogenic bile.

Given that newly described interstitial cells, telocytes, are present in the gallbladder and they are located in close vicinity of smooth muscle cell and neural fibers possibly interfering with gallbladder motility or contractility, authors are trying to summarize the current knowledge on the role of telocytes with respect to disturbed gallbladder function in gallstone disease.


Telocytes Gallstone disease Cholesterol saturation index Bile lithogenicity 



The authors acknowledge the involvement of many colleagues who have participated in our studies and contributed with helpful discussions.


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Copyright information

© Springer Science+Business Media Singapore 2016

Authors and Affiliations

  • Artur Pasternak
    • 1
    • 2
  • Krzysztof Gil
    • 3
  • Andrzej Matyja
    • 1
  1. 1.First Department of General, Oncological and Gastrointestinal SurgeryJagiellonian University Medical CollegeKrakowPoland
  2. 2.Department of AnatomyJagiellonian University Medical CollegeKrakowPoland
  3. 3.Department of PathophysiologyJagiellonian University Medical CollegeKrakowPoland

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