Telocytes pp 425-432

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 913) | Cite as

Hepatic Telocytes

  • Yingying Zhao
  • Xiaoyu Chen
  • Fei Wang
  • Changqing Yang
Chapter

Abstract

Telocytes (TCs), a novel peculiar interstitial cell found in many tissues and organs, play pivotal roles in maintaining tissue homeostasis and regulating tissue and organ development and immune surveillance. In recent years, the existence of TCs in liver has been confirmed. In this chapter, we evaluate the role of TCs on promoting liver regeneration and the therapeutic effects on liver fibrosis.

Keywords

Telocytes Liver Liver regeneration Liver fibrosis 

References

  1. 1.
    Llinas RR. The contribution of santiago ramon y cajal to functional neuroscience. Nat Rev Neurosci. 2003;4:77–80.CrossRefPubMedGoogle Scholar
  2. 2.
    Faussone Pellegrini MS, Cortesini C, Romagnoli P. Nature and significance of the so-called cajal’s “interstitial cells” in the human esophagus and stomach. Boll Soc Ital Biol Sper. 1976;52:1764–7.PubMedGoogle Scholar
  3. 3.
    Faussone Pellegrini MS, Cortesini C, Romagnoli P. Ultrastructure of the tunica muscularis of the cardial portion of the human esophagus and stomach, with special reference to the so-called cajal’s interstitial cells. Arch Ital Anat Embriol Ital J Anat Embryol. 1977;82:157–77.Google Scholar
  4. 4.
    Thuneberg L, Rumessen JJ, Mikkelsen HB. Interstitial cells of cajal – an intestinal impulse generation and conduction system? Scand J Gastroenterol Suppl. 1982;71:143–4.PubMedGoogle Scholar
  5. 5.
    Christensen J. A commentary on the morphological identification of interstitial cells of cajal in the gut. J Auton Nerv Syst. 1992;37:75–88.CrossRefPubMedGoogle Scholar
  6. 6.
    Popescu LM, Faussone-Pellegrini MS. Telocytes – a case of serendipity: the winding way from interstitial cells of cajal (icc), via interstitial cajal-like cells (iclc) to telocytes. J Cell Mol Med. 2010;14:729–40.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Popescu LM, Hinescu ME, Ionescu N, Ciontea SM, Cretoiu D, Ardelean C. Interstitial cells of cajal in pancreas. J Cell Mol Med. 2005;9:169–90.CrossRefPubMedGoogle Scholar
  8. 8.
    Gherghiceanu M, Popescu LM. Interstitial cajal-like cells (iclc) in human resting mammary gland stroma. Transmission electron microscope (tem) identification. J Cell Mol Med. 2005;9:893–910.CrossRefPubMedGoogle Scholar
  9. 9.
    Radu E, Regalia T, Ceafalan L, Andrei F, Cretoiu D, Popescu LM. Cajal-type cells from human mammary gland stroma: phenotype characteristics in cell culture. J Cell Mol Med. 2005;9:748–52.CrossRefPubMedGoogle Scholar
  10. 10.
    Popescu LM, Andrei F, Hinescu ME. Snapshots of mammary gland interstitial cells: methylene-blue vital staining and c-kit immunopositivity. J Cell Mol Med. 2005;9:476–7.CrossRefPubMedGoogle Scholar
  11. 11.
    Hinescu ME, Ardeleanu C, Gherghiceanu M, Popescu LM. Interstitial cajal-like cells in human gallbladder. J Mol Histol. 2007;38:275–84.CrossRefPubMedGoogle Scholar
  12. 12.
    Popescu LM, Ciontea SM, Cretoiu D, Hinescu ME, Radu E, Ionescu N, Ceausu M, Gherghiceanu M, Braga RI, Vasilescu F, Zagrean L, Ardeleanu C. Novel type of interstitial cell (cajal-like) in human fallopian tube. J Cell Mol Med. 2005;9:479–523.CrossRefPubMedGoogle Scholar
  13. 13.
    Popescu LM, Ciontea SM, Cretoiu D. Interstitial cajal-like cells in human uterus and fallopian tube. Ann N Y Acad Sci. 2007;1101:139–65.CrossRefPubMedGoogle Scholar
  14. 14.
    Cretoiu SM, Cretoiu D, Suciu L, Popescu LM. Interstitial cajal-like cells of human fallopian tube express estrogen and progesterone receptors. J Mol Histol. 2009;40:387–94.CrossRefPubMedGoogle Scholar
  15. 15.
    Suciu L, Popescu LM, Gherghiceanu M, Regalia T, Nicolescu MI, Hinescu ME, Faussone-Pellegrini MS. Telocytes in human term placenta: morphology and phenotype. Cells Tissues Organs. 2010;192:325–39.CrossRefPubMedGoogle Scholar
  16. 16.
    Suciu L, Popescu LM, Gherghiceanu M. Human placenta: De visu demonstration of interstitial cajal-like cells. J Cell Mol Med. 2007;11:590–7.CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Popescu LM, Manole E, Serboiu CS, Manole CG, Suciu LC, Gherghiceanu M, Popescu BO. Identification of telocytes in skeletal muscle interstitium: implication for muscle regeneration. J Cell Mol Med. 2011;15:1379–92.CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Gherghiceanu M, Manole CG, Popescu LM. Telocytes in endocardium: electron microscope evidence. J Cell Mol Med. 2010;14:2330–4.CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Hinescu ME, Popescu LM. Interstitial cajal-like cells (iclc) in human atrial myocardium. J Cell Mol Med. 2005;9:972–5.CrossRefPubMedGoogle Scholar
  20. 20.
    Hinescu ME, Gherghiceanu M, Mandache E, Ciontea SM, Popescu LM. Interstitial cajal-like cells (iclc) in atrial myocardium: ultrastructural and immunohistochemical characterization. J Cell Mol Med. 2006;10:243–57.CrossRefPubMedGoogle Scholar
  21. 21.
    Popescu LM, Gherghiceanu M, Hinescu ME, Cretoiu D, Ceafalan L, Regalia T, Popescu AC, Ardeleanu C, Mandache E. Insights into the interstitium of ventricular myocardium: interstitial cajal-like cells (iclc). J Cell Mol Med. 2006;10:429–58.CrossRefPubMedGoogle Scholar
  22. 22.
    Kostin S, Popescu LM. A distinct type of cell in myocardium: interstitial cajal-like cells (iclcs). J Cell Mol Med. 2009;13:295–308.CrossRefPubMedPubMedCentralGoogle Scholar
  23. 23.
    Suciu L, Popescu LM, Regalia T, Ardelean A, Manole CG. Epicardium: interstitial cajal-like cells (iclc) highlighted by immunofluorescence. J Cell Mol Med. 2009;13:771–7.CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Gherghiceanu M, Popescu LM. Human epicardium: ultrastructural ancestry of mesothelium and mesenchymal cells. J Cell Mol Med. 2009;13:2949–51.CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Popescu LM, Gherghiceanu M, Suciu LC, Manole CG, Hinescu ME. Telocytes and putative stem cells in the lungs: electron microscopy, electron tomography and laser scanning microscopy. Cell Tissue Res. 2011;345:391–403.CrossRefPubMedPubMedCentralGoogle Scholar
  26. 26.
    Zheng Y, Li H, Manole CG, Sun A, Ge J, Wang X. Telocytes in trachea and lungs. J Cell Mol Med. 2011;15:2262–8.CrossRefPubMedPubMedCentralGoogle Scholar
  27. 27.
    Cretoiu SM, Popescu LM. Telocytes revisited. Biomol Concepts. 2014;5:353–69.CrossRefPubMedGoogle Scholar
  28. 28.
    Vannucchi MG, Traini C, Manetti M, Ibba-Manneschi L, Faussone-Pellegrini MS. Telocytes express pdgfralpha in the human gastrointestinal tract. J Cell Mol Med. 2013;17:1099–108.CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Zheng Y, Bai C, Wang X. Telocyte morphologies and potential roles in diseases. J Cell Physiol. 2012;227:2311–7.CrossRefPubMedGoogle Scholar
  30. 30.
    Popescu LM, Manole CG, Gherghiceanu M, Ardelean A, Nicolescu MI, Hinescu ME, Kostin S. Telocytes in human epicardium. J Cell Mol Med. 2010;14:2085–93.CrossRefPubMedPubMedCentralGoogle Scholar
  31. 31.
    Bani D, Formigli L, Gherghiceanu M, Faussone-Pellegrini MS. Telocytes as supporting cells for myocardial tissue organization in developing and adult heart. J Cell Mol Med. 2010;14:2531–8.CrossRefPubMedPubMedCentralGoogle Scholar
  32. 32.
    Manole CG, Cismasiu V, Gherghiceanu M, Popescu LM. Experimental acute myocardial infarction: telocytes involvement in neo-angiogenesis. J Cell Mol Med. 2011;15:2284–96.CrossRefPubMedPubMedCentralGoogle Scholar
  33. 33.
    Bojin FM, Gavriliuc OI, Cristea MI, Tanasie G, Tatu CS, Panaitescu C, Paunescu V. Telocytes within human skeletal muscle stem cell niche. J Cell Mol Med. 2011;15:2269–72.CrossRefPubMedPubMedCentralGoogle Scholar
  34. 34.
    Sheng J, Shim W, Lu J, Lim SY, Ong BH, Lim TS, Liew R, Chua YL, Wong P. Electrophysiology of human cardiac atrial and ventricular telocytes. J Cell Mol Med. 2014;18:355–62.CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    Xiao J, Wang F, Liu Z, Yang C. Telocytes in liver: electron microscopic and immunofluorescent evidence. J Cell Mol Med. 2013;17:1537–42.CrossRefPubMedPubMedCentralGoogle Scholar
  36. 36.
    Bei Y, Zhou Q, Fu S, Lv D, Chen P, Chen Y, Wang F, Xiao J. Cardiac telocytes and fibroblasts in primary culture: different morphologies and immunophenotypes. PLoS One. 2015;10:e0115991.CrossRefPubMedPubMedCentralGoogle Scholar
  37. 37.
    Zimmermann A. Liver regeneration: the emergence of new pathways. Med Sci Monit Int Med J Exp Clin Res. 2002;8:RA53–63.Google Scholar
  38. 38.
    Fausto N. Liver regeneration. J Hepatol. 2000;32:19–31.CrossRefPubMedGoogle Scholar
  39. 39.
    Gilgenkrantz H. Collin de l’Hortet A: new insights into liver regeneration. Clin Res Hepatol Gastroenterol. 2011;35:623–9.CrossRefPubMedGoogle Scholar
  40. 40.
    Wang F, Song Y, Bei Y, Zhao Y, Xiao J, Yang C. Telocytes in liver regeneration: possible roles. J Cell Mol Med. 2014;18:1720–6.CrossRefPubMedPubMedCentralGoogle Scholar
  41. 41.
    Li LC, Gao J, Li J. Emerging role of hmgb1 in fibrotic diseases. J Cell Mol Med. 2014;18:2331–9.CrossRefPubMedPubMedCentralGoogle Scholar
  42. 42.
    Wynn TA, Ramalingam TR. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med. 2012;18:1028–40.CrossRefPubMedPubMedCentralGoogle Scholar
  43. 43.
    Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA, Hofmann AF, Iida T, Glass CK, Brenner DA, Kisseleva T. Origin of myofibroblasts in the fibrotic liver in mice. Proc Natl Acad Sci U S A. 2014;111:E3297–305.CrossRefPubMedPubMedCentralGoogle Scholar
  44. 44.
    Zhao B, Chen S, Liu J, Yuan Z, Qi X, Qin J, Zheng X, Shen X, Yu Y, Qnin TJ, Chan JY, Cai D. Cardiac telocytes were decreased during myocardial infarction and their therapeutic effects for ischaemic heart in rat. J Cell Mol Med. 2013;17:123–33.CrossRefPubMedGoogle Scholar
  45. 45.
    Fu S, Wang F, Cao Y, Huang Q, Xiao J, Yang C, Popescu LM. Telocytes in human liver fibrosis. J Cell Mol Med. 2015;19:676–83.CrossRefPubMedPubMedCentralGoogle Scholar
  46. 46.
    Cismasiu VB, Popescu LM. Telocytes transfer extracellular vesicles loaded with micrornas to stem cells. J Cell Mol Med. 2015;19:351–8.CrossRefPubMedPubMedCentralGoogle Scholar
  47. 47.
    Zhao B, Liao Z, Chen S, Yuan Z, Yilin C, Lee KK, Qi X, Shen X, Zheng X, Quinn T, Cai D. Intramyocardial transplantation of cardiac telocytes decreases myocardial infarction and improves post-infarcted cardiac function in rats. J Cell Mol Med. 2014;18:780–9.CrossRefPubMedPubMedCentralGoogle Scholar
  48. 48.
    Diaz-Flores L, Gutierrez R, Saez FJ, Diaz-Flores Jr L, Madrid JF. Telocytes in neuromuscular spindles. J Cell Mol Med. 2013;17:457–65.CrossRefPubMedPubMedCentralGoogle Scholar
  49. 49.
    Kuehbacher A, Urbich C, Zeiher AM, Dimmeler S. Role of dicer and drosha for endothelial microrna expression and angiogenesis. Circ Res. 2007;101:59–68.CrossRefPubMedGoogle Scholar
  50. 50.
    Otsuka M, Zheng M, Hayashi M, Lee JD, Yoshino O, Lin S, Han J. Impaired microrna processing causes corpus luteum insufficiency and infertility in mice. J Clin Invest. 2008;118:1944–54.CrossRefPubMedPubMedCentralGoogle Scholar
  51. 51.
    Shen X, Fang J, Lv X, Pei Z, Wang Y, Jiang S, Ding K. Heparin impairs angiogenesis through inhibition of microrna-10b. J Biol Chem. 2011;286:26616–27.CrossRefPubMedPubMedCentralGoogle Scholar
  52. 52.
    Wang S, Aurora AB, Johnson BA, Qi X, McAnally J, Hill JA, Richardson JA, Bassel-Duby R, Olson EN. The endothelial-specific microrna mir-126 governs vascular integrity and angiogenesis. Dev Cell. 2008;15:261–71.CrossRefPubMedPubMedCentralGoogle Scholar
  53. 53.
    Urbich C, Kuehbacher A, Dimmeler S. Role of micrornas in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res. 2008;79:581–8.CrossRefPubMedGoogle Scholar
  54. 54.
    Caporali A, Meloni M, Vollenkle C, Bonci D, Sala-Newby GB, Addis R, Spinetti G, Losa S, Masson R, Baker AH, Agami R, le Sage C, Condorelli G, Madeddu P, Martelli F, Emanueli C. Deregulation of microrna-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia. Circulation. 2011;123:282–91.CrossRefPubMedGoogle Scholar
  55. 55.
    Chen Y, Gorski DH. Regulation of angiogenesis through a microrna (mir-130a) that down-regulates antiangiogenic homeobox genes gax and hoxa5. Blood. 2008;111:1217–26.CrossRefPubMedPubMedCentralGoogle Scholar
  56. 56.
    Manetti M, Guiducci S, Ruffo M, Rosa I, Faussone-Pellegrini MS, Matucci-Cerinic M, Ibba-Manneschi L. Evidence for progressive reduction and loss of telocytes in the dermal cellular network of systemic sclerosis. J Cell Mol Med. 2013;17:482–96.CrossRefPubMedPubMedCentralGoogle Scholar
  57. 57.
    Mou Y, Wang Y, Li J, Lu S, Duan C, Du Z, Yang G, Chen W, Zhao S, Zhou J, Wang C. Immunohistochemical characterization and functional identification of mammary gland telocytes in the self-assembly of reconstituted breast cancer tissue in vitro. J Cell Mol Med. 2013;17:65–75.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media Singapore 2016

Authors and Affiliations

  • Yingying Zhao
    • 1
  • Xiaoyu Chen
    • 1
  • Fei Wang
    • 1
  • Changqing Yang
    • 1
  1. 1.Division of Gastroenterology and Hepatology, Digestive Disease InstituteShanghai Tongji Hospital, Tongji University School of MedicineShanghaiChina

Personalised recommendations