Telocytes pp 335-357 | Cite as

Immunohistochemistry of Telocytes in the Uterus and Fallopian Tubes

  • Sanda Maria Cretoiu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 913)


The seminal work of Popescu and colleagues first demonstrated the existence of a new cell type – the telocytes. We were among the first who reported the presence of such cells in the female genital tract and performed TEM examinations, as well as immunohistochemical staining in the attempt to find a specific marker. Telocytes from rat and from the human uterus and from human fallopian tube were extensively investigated initially by comparison with interstitial cells of Cajal. Progress in telocyte research led to the identification of different subtypes suggestive for a heterogeneous telocyte population which can even coexist in the same location. As a consequence, the functions of TCs are still elusive and can be considered a versatile phenomenon that depends on a variety of conditions, including signal reception and transmission of information via extracellular vesicles or by direct intercellular contact.


Telocytes Telopodes Immunocytochemical phenotype Uterus Fallopian tube 



This work was supported by the Romanian National Authority for Scientific Research CNCS-UEFISCDI project numbers 82/2012 and 194/2014.


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Copyright information

© Springer Science+Business Media Singapore 2016

Authors and Affiliations

  1. 1.Victor Babeş National Institute of PathologyBucharestRomania
  2. 2.Division of Cell Biology and HistologyCarol Davila University of Medicine and PharmacyBucharestRomania

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