Telocytes pp 287-302

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 913) | Cite as

Electrophysiological Features of Telocytes

  • Daniel Dumitru Banciu
  • Adela Banciu
  • Beatrice Mihaela Radu
Chapter

Abstract

Telocytes (TCs) are interstitial cells described in multiple structures, including the gastrointestinal tract, respiratory tract, urinary tract, uterus, and heart. Several studies have indicated the possibility that TCs are involved in the pacemaker potential in these organs. It is supposed that TCs are interacting with the neighboring muscular cells and their network contributes to the initiation and propagation of the electrical potentials. In order to understand the contribution of TCs to various excitability mechanisms, it is necessary to analyze the plasma membrane proteins (e.g., ion channels) functionally expressed in these cells. So far, potassium, calcium, and chloride currents, but not sodium currents, have been described in TCs in primary cell culture from different tissues. Moreover, TCs have been described as sensors for mechanical stimuli (e.g., contraction, extension, etc.). In conclusion, TCs might play an essential role in gastrointestinal peristalsis, in respiration, in pregnant uterus contraction, or in miction, but further highlighting studies are necessary to understand the molecular mechanisms and the cell-cell interactions by which TCs contribute to the tissue excitability and pacemaker potentials initiation/propagation.

Keywords

Telocytes Interstitial cells of Cajal In vitro electrophysiology Patch clamp Potassium currents Calcium currents Chloride currents Pacemaker potential 

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Copyright information

© Springer Science+Business Media Singapore 2016

Authors and Affiliations

  • Daniel Dumitru Banciu
    • 1
  • Adela Banciu
    • 1
  • Beatrice Mihaela Radu
    • 1
    • 2
  1. 1.Department of Anatomy, Animal Physiology and Biophysics, Faculty of BiologyUniversity of BucharestBucharestRomania
  2. 2.Department of Neurological and Movement SciencesUniversity of VeronaVeronaItaly

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