Telocytes pp 177-191 | Cite as

Telocyte Behaviour During Inflammation, Repair and Tumour Stroma Formation

  • L. Díaz-Flores
  • R. Gutiérrez
  • M. González-Gómez
  • L. Díaz-FloresJr
  • F. Valladares
  • N. Rancel
  • F. J. Sáez
  • J. F. Madrid
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 913)


In this chapter, we outline the role of human CD34+ stromal cells/telocytes (CD34+ SC/TCs) as progenitor cells during repair. The in vivo activation phenomena of CD34+ SC/TCs in this process include increased size; separation from the neighbouring structures (mainly of the vascular walls); association with inflammatory cells, predominantly macrophages; development of the organelles of synthesis (rough endoplasmic reticulum and Golgi apparatus); cell proliferation with presence of mitosis and high proliferative index (transit-amplifying cells); and fibroblastic and myofibroblastic differentiation. A procedure to study these tissue-resident cells, comparison of their behaviour in vivo and in vitro and different behaviour depending on location, time, type of injury (including tumour stroma) and greater or lesser proximity to the injury are also considered.


Progenitor Cell Stromal Cell Stem Cell Niche Stromal Vascular Fraction Proliferative Stage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Singapore 2016

Authors and Affiliations

  • L. Díaz-Flores
    • 1
  • R. Gutiérrez
    • 1
  • M. González-Gómez
    • 1
  • L. Díaz-FloresJr
    • 1
  • F. Valladares
    • 1
  • N. Rancel
    • 1
  • F. J. Sáez
    • 2
  • J. F. Madrid
    • 3
  1. 1.Department of Anatomy, Pathology, Histology and Radiology, Faculty of MedicineUniversity of La LagunaTenerifeSpain
  2. 2.Department of Cell Biology and Histology, UFI11/44, School of Medicine and DentistryUniversity of the Basque Country, UPV/EHULeioaSpain
  3. 3.Department of Cell Biology and Histology, School of MedicineRegional Campus of International Excellence, “Campus Mare Nostrum” University of MurciaMurciaSpain

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