Stroma is viewed as the supportive framework of a predominant epithelial organ, comprising mostly of connective tissue, blood vessels and nerves. Since the discovery of telocytes one decade ago (Popescu and Faussone-Pellegrini J Cell Mol Med 2010;14(4):729–40), their presence was proven in several exocrine gland stromata, including major and minor salivary glands, mammary glands as well as exocrine pancreas.
Telocytes have been found in a close connection with acinar and ductal structures but also with their stromal neighbours – nerves, blood vessels or other connective elements, either cells or collagen fibres.
The approaches used to reveal the telocytes’ location were immunohistochemistry and electron microscopy.
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