The History of Drug Delivery Systems

  • Hamid Reza RezaieEmail author
  • Mohammadhossein Esnaashary
  • Abolfazl Aref arjmand
  • Andreas Öchsner
Part of the SpringerBriefs in Applied Sciences and Technology book series (BRIEFSAPPLSCIENCES)


Each drug has some pharmacological properties that can produce biological effects on the human body; these effects are engendered by the interactions between the drug and specific receptors at the drug’s site of action.


  1. 1.
    Hillery AM, Park K (2017) Drug delivery: fundamentals & applications, 2nd edn. CRC PressGoogle Scholar
  2. 2.
    Gennaro AR (2000) Remington: the science and practice of pharmacy, Twentieth. Lippincott Williams & WilkinsGoogle Scholar
  3. 3.
    Langer RS, Peppas NA (1981) Present and future applications of biomaterials in controlled drug delivery systems. Biomaterials 2:201–214. Scholar
  4. 4.
    Perrie Y, Rades T (2009) Pharmaceutics: drug delivery and targeting, 1st edn. Pharmaceutical PressGoogle Scholar
  5. 5.
    Akala EO (2004) Oral controlled release solid dosage forms. In: Theory and practice of contemporary pharmaceutics. CRC PressCrossRefGoogle Scholar
  6. 6.
    Wilson CG, Crowley PJ (2011) Controlled release in oral drug delivery. Springer, US, Boston, MACrossRefGoogle Scholar
  7. 7.
    Mehrotra N, Gupta M, Kovar A, Meibohm B (2007) The role of pharmacokinetics and pharmacodynamics in phosphodiesterase-5 inhibitor therapy. Int J Impot Res 19:253–264. Scholar
  8. 8.
    Akiti O, Jimoh AG, Wise DL, Barabino GA, Trantolo DJ, Gresser JD (1996) Multiphasic or “Pulsatile” controlled release system for the delivery of vaccines. In: Wise DL, Trantolo DJ, Altobelli DE, Yaszemski MJ, Gresser JD (eds) Human biomaterials applications. Humana Press, Totowa, NJ, pp 319–343CrossRefGoogle Scholar
  9. 9.
    Zhang W, Zhao Q, Deng J, Hu Y, Wang Y, Ouyang D (2017) Big data analysis of global advances in pharmaceutics and drug delivery 1980–2014. Drug Discov Today 22:1201–1208. Scholar
  10. 10.
    Park K (2014) Controlled drug delivery systems: past forward and future back. J Control Release 190:3–8. Scholar
  11. 11.
    Park K (2016) Drug delivery of the future: chasing the invisible gorilla. J Control Release 240:2–8. Scholar
  12. 12.
    Gupta P, Vermani K, Garg S (2002) Hydrogels: from controlled release to pH-responsive drug delivery. Drug Discov Today 7:569–579. Scholar
  13. 13.
    Brannon-Peppas L (1995) Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery. Int J Pharm 116:1–9. Scholar
  14. 14.
    Rosen HB, Chang J, Wnek GE, Linhardt RJ, Langer R (1983) Bioerodible polyanhydrides for controlled drug delivery. Biomaterials 4:131–133. Scholar
  15. 15.
    Hatefi A, Amsden B (2002) Biodegradable injectable in situ forming drug delivery systems. J Control Release 80:9–28. Scholar
  16. 16.
    Yun YH, Lee BK, Park K (2015) Controlled drug delivery: historical perspective for the next generation. J Control Release 219:2–7. Scholar
  17. 17.
    He CX, He ZG, Gao JQ (2010) Microemulsions as drug delivery systems to improve the solubility and the bioavailability of poorly water-soluble drugs. Expert Opin Drug Deliv 7:445–460. Scholar
  18. 18.
    Rawat M, Singh D, Saraf S (2008) Lipid carriers: a versatile delivery vehicle for proteins and peptides. Yakugaku Zasshi 128:269–280. Scholar

Copyright information

© The Author(s) 2018

Authors and Affiliations

  • Hamid Reza Rezaie
    • 1
    Email author
  • Mohammadhossein Esnaashary
    • 1
  • Abolfazl Aref arjmand
    • 1
  • Andreas Öchsner
    • 2
  1. 1.Department of Engineering Materials, Ceramic and Biomaterial DivisionIran University of Science and TechnologyTehranIran
  2. 2.Faculty of Mechanical EngineeringEsslingen University of Applied SciencesEsslingenGermany

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