Development of a Piezoelectric Flexural Plate-Wave (FPW) Biomems-Sensor for Rapid Point-of-Care Diagnostics
A high rate of post-neonatal deaths is due to a Respiratory Syncytial Virus (RSV). An early diagnosis with the accurate patient stratification and forecast of disease outcome is vital for an effective treatment. Common diagnostics for the identification of unknown pathogens require large sample volumes and are laborious. In this work, a novel piezoelectric FPW Bio-MEMS sensor based on the frequency shift of a resonating membrane due to binding of an additional mass was developed. The experimental results show that the sensor, a critical part of point-of-care devices, can detect with a high degree of accuracy RSV chemokines in complex media and is much faster than standard methods.
KeywordsFlexural plate wave (FPW) Bio-MEMS sensor Ultra-sensitive point-of-care diagnostics Detection of causative agent of the infection Host response in blood and nasopharyngeal aspirate
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 634415.
- 3.Point of care testing: applications of microfluidic technologies. Report May 2014 (Yole-Developement, 2014)Google Scholar
- 8.WHO (2009) Infant mortality from respiratory diseases. Fact Sheet CODE: RPG3_Air_E2Google Scholar
- 10.Shruthi GS, Amitha CV, Mathew BB (2014) Biosensors: a modern day achievement. J Instrum Technol 2(1):26Google Scholar
- 12.Huang IY, Lee MC (2006) Development of a novel flexural plate wave biosensor for immunoglobulin-E detection by using SAM and MEMS technologies. In: Proceedings of the 5th IEEE conference on sensors (IEEE sensors 2006), Daegu, 22–25 Oct 2006Google Scholar
- 13.Huang IY, Lee MC, Chang YW, Huang RS (2007) Development and characterization of FPW based allergy biosensor. In: Proceedings of the 2007 IEEE international symposium on industrial electronics (IEEE ISIE 2007), Vigo, 4–7 JuneGoogle Scholar
- 14.Huang IY, Lee MC (2008) Development of a FPW allergy biosensor using NEMS technology. In: Proceedings of the 2008 Asia-Pacific conference on transducers and micro-nano technology (APCOT 2008), Tainan, 22–25 June 2008Google Scholar
- 16.Ballantine DS Jr, White RM, Martin SJ, Ricco AJ, Frye GC, Zellers ET, Wohltjec H (1997) Acoustic wave sensors: theory, design, and physicochemical application. Academic, New YorkGoogle Scholar