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Development of a Piezoelectric Flexural Plate-Wave (FPW) Biomems-Sensor for Rapid Point-of-Care Diagnostics

  • A. Jupe
  • P. Livshits
  • S. Kahnert
  • M. Figge
  • S. Mross
  • M. Goertz
  • H. Kappert
  • H. Vogt
  • A. Goehlich
Conference paper
Part of the NATO Science for Peace and Security Series A: Chemistry and Biology book series (NAPSA)

Abstract

A high rate of post-neonatal deaths is due to a Respiratory Syncytial Virus (RSV). An early diagnosis with the accurate patient stratification and forecast of disease outcome is vital for an effective treatment. Common diagnostics for the identification of unknown pathogens require large sample volumes and are laborious. In this work, a novel piezoelectric FPW Bio-MEMS sensor based on the frequency shift of a resonating membrane due to binding of an additional mass was developed. The experimental results show that the sensor, a critical part of point-of-care devices, can detect with a high degree of accuracy RSV chemokines in complex media and is much faster than standard methods.

Keywords

Flexural plate wave (FPW) Bio-MEMS sensor Ultra-sensitive point-of-care diagnostics Detection of causative agent of the infection Host response in blood and nasopharyngeal aspirate 

Notes

Acknowledgements

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 634415.

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • A. Jupe
    • 1
  • P. Livshits
    • 1
  • S. Kahnert
    • 1
  • M. Figge
    • 1
  • S. Mross
    • 1
  • M. Goertz
    • 1
  • H. Kappert
    • 1
  • H. Vogt
    • 1
  • A. Goehlich
    • 1
  1. 1.Fraunhofer Institute for Microelectronic Circuits and Systems IMSDuisburgGermany

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