Genetic Aberrations and Molecular Pathways in Head and Neck Cancer

  • Luis MonteiroEmail author
  • Saman Warnakulasuriya


In this chapter, we provide a comprehensive overview of common genetic aberrations so far discovered in head and neck cancer. We discuss how these genetic alterations may affect protein structure and function. We also highlight the latest discoveries in signalling pathways affected as a result of these genetic aberrations. A better understanding of these mechanisms underlying cancer formation, progression and resistance to therapy leads us to the next five chapters that discuss each of the key driver mutations and tumour suppressors that are lost in head and neck cancer.


EGFREpidermal Growth Factor Receptor Oral Cancer Vascular Endothelial Growth Factor Receptor EGFREpidermal Growth Factor Receptor Mutation EGFREpidermal Growth Factor Receptor Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  1. 1.Department of Medicine and Oral Surgery, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde (IINFACTS), Instituto Universitário de Ciências da Saúde (IUCS)CESPUGandraPortugal
  2. 2.Oral Medicine and Experimental PathologyKing’s College LondonLondonUK

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