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Taurine 10 pp 621-631 | Cite as

Hepatoprotective Effects of Xylose-Taurine Reduced Against Hydrogen Peroxide-Induced Oxidative Stress in Cultured Hepatocytes

  • Soo Yeon Park
  • Chang-Bum Ahn
  • Kyung Ja Chang
  • Sung Hoon Kim
  • WonWoo Lee
  • Ju Hyung Um
  • Eui Jeong Han
  • You-Jin Jeon
  • Sun Hee CheongEmail author
  • Ginnae AhnEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 975)

Abstract

In this study, Xylose-Taurine reduced (X-T-R) was synthesized to enhance biological activities. Hence, we investigated the hepatoprotective effects of X-T-R against H2O2-induced hepatocyte damage and apoptosis. The results showed that X-T-R led to the cytoprotective effect against H2O2-induced oxidative stress in cultured hepatocytes such as the improvement of cell viability and the reduction of reactive oxygen species (ROS) production. Additionally, pre-treatment with X-T-R increased the expression of nuclear factor erythroid 2-related factor 2 (Nrf2), NAD(P)H dehydrogenase:quinone 1 (NQO1) and heme oxygenase 1 (HO-1) in cultured hepatocytes. Furthermore, X-T-R protected the cells against apoptosis via regulating the expression level of Bcl-2/Bax as well as the activation of caspase-3. According to the results obtained, X-T-R may be a bio-material for the therapy of hepatic diseases.

Keywords

Xylose-Taurine reduced Hepatoprotective effects Oxidative stress Hepatocytes 

Abbreviations

HO-1

Heme oxygenase 1

NQO1

NAD(P)H dehydrogenase:quinone

Nrf2

Nuclear factor erythroid 2-related factor 2

X-T-R

Xylose-Taurine reduced

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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Soo Yeon Park
    • 1
  • Chang-Bum Ahn
    • 1
    • 2
  • Kyung Ja Chang
    • 3
  • Sung Hoon Kim
    • 4
  • WonWoo Lee
    • 5
  • Ju Hyung Um
    • 1
  • Eui Jeong Han
    • 1
  • You-Jin Jeon
    • 5
  • Sun Hee Cheong
    • 1
    • 6
    Email author
  • Ginnae Ahn
    • 1
    • 6
    Email author
  1. 1.Department of Food Technology and NutritionChonnam National UniversityYeosuSouth Korea
  2. 2.Division of Food and NutritionChonnam National UniversityGwang juSouth Korea
  3. 3.Department of Food and NutritionInha UniversityIncheonSouth Korea
  4. 4.Department of ChemistryKonkuk UniversitySeoulSouth Korea
  5. 5.Department of Marine Life ScienceJeju National UniversityJejuSouth Korea
  6. 6.Department of Marine Bio-Food SciencesChonnam National UniversityYeosuSouth Korea

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