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Taurine 10 pp 225-232 | Cite as

Taurine-Carbohydrate Derivative Stimulates Fibrillogenesis of Amyloid-β and Reduce Alzheimer-Like Behaviors

  • Hye Yun Kim
  • Seung-Hoon Yang
  • Jin Yoon
  • HoChung Jang
  • Seungyeop Baek
  • Jisu Shin
  • Sung Hoon KimEmail author
  • YoungSoo KimEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 975)

Abstract

Amyloid-β (Aβ) aggregates are a hallmark of Alzheimer’s disease (AD). Through the misfolding process of Aβ in the brain, oligomeric forms of Aβ accumulate and significantly damage the brain cells inducing neuronal loss and cognitive dysfunctions that lead to AD. We hypothesized that decrease in Aβ oligomers during the aggregation process might be able to reduce Aβ-dependent brain damage. As taurine-like chemicals are often reported to have direct binding abilities to Aβ, we prepared a chemical library that consisted of taurine-carbohydrate derivatives to search for molecules that target Aβ and accelerate its fibrillogenesis. Here, we report that 1-deoxy-1-(2-sulfoethylamino)-D-fructose stimulates the formation of relatively less toxic Aβ fibrils leading to prevention of cognitive deficits in AD acute model mice.

Keywords

Taurine-fructose derivative Prevention of cognitive deficits 

Abbreviations

AD

Alzheimer’s disease

Amyloid-β

Notes

Acknowledgements

This work was supported by KHIDI (HI14C0466).

References

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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Hye Yun Kim
    • 1
  • Seung-Hoon Yang
    • 2
  • Jin Yoon
    • 2
    • 3
  • HoChung Jang
    • 1
    • 2
    • 4
  • Seungyeop Baek
    • 2
    • 5
  • Jisu Shin
    • 1
  • Sung Hoon Kim
    • 6
    Email author
  • YoungSoo Kim
    • 1
    Email author
  1. 1.Department of pharmacy and Integrated Science and EngineeringYonsei UniversityYeonsu-guSouth Korea
  2. 2.Brain Science Institute, Korea Institute of Science and Technology (KIST) Hwarangno 24-gil 5Seongbuk-guSouth Korea
  3. 3.Department of BiologyMassachusetts Institute of TechnologyBostonUSA
  4. 4.Department of Biological Chemistry, Korea University of Science and Technology (UST)217 Gajungro Yuseong-guDaegeonSouth Korea
  5. 5.Department of BiotechnologyYonsei UniversitySeodaemun-guSouth Korea
  6. 6.Department of ChemistryKonkuk UniversitySeoulSouth Korea

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