Advertisement

Amniotic Membrane in the Treatment of Burns

Chapter

Abstract

Burn wound dressing represents an important aspect of burn care. The various inherent features of amniotic membrane proved to be useful as it contributes towards the attributes of an ideal dressing. This biological dressing is inexpensive, able to enhance re-epithelialization, readily available and stored, hence rendering it suitable for a wide range of burn wound treatment. The different preparations of amniotic membrane provide additional benefit whereby clinicians can have a range of product to choose from. Pain relief, good wound adherence and conformability further increase the importance of amnion as burn wound dressing. The versatility and efficacy of the amnion makes it an attractive option despite of the enormous range commercially available wound management products in the market. This chapter presents a review of the various aspects of amniotic membrane for burn wound treatment.

Keywords

Amnion Burns Wound healing Wound dressing Biological dressing 

References

  1. 1.
    WHO (2012) Burns – fact sheet. http://www.who.int/mediacentre/factsheets/fs365/en/
  2. 2.
    ABA (2012) Burn incidence fact sheet. http://www.ameriburn.org/resources_factsheet.php
  3. 3.
    Tyszkiewicz J, Uhrynowska-Tyszkiewicz I, Kaminski A, Dziedzic-Goclawska A (1999) Amnion allografts prepared in the central tissue bank in Warsaw. Ann Transplant 4:85–90PubMedGoogle Scholar
  4. 4.
    Davis J (1910) Skin transplantation with a review of 550 cases at the Johns Hopkins hospital. Johns Hopkins Hosp Rep 15:307–395Google Scholar
  5. 5.
    Subrahmanyam M (1995) Amniotic membrane as a cover for microskin grafts. Br J Plast Surg 48:477–478PubMedCrossRefGoogle Scholar
  6. 6.
    Ward D, Bennett J, Burgos H, Fabre J (1989) The healing of chronic venous leg ulcers with prepared human amnion. Br J Plast Surg 42:463–467PubMedCrossRefGoogle Scholar
  7. 7.
    Gajiwala AL, Sharma V (2003) Use of irradiated amnion as a biological dressing in the treatment of radiation induced ulcers. Cell Tissue Bank 4:147–150CrossRefGoogle Scholar
  8. 8.
    Ravishanker R, Bath A, Roy R (2003) “Amnion Bank” – the use of long term glycerol preserved amniotic membranes in the management of superficial and superficial partial thickness burns. Burns 29:369–374PubMedCrossRefGoogle Scholar
  9. 9.
    Mohammadi AA, Sabet B, Riazi H et al (2009) Human amniotic membrane dressing: an excellent method for outpatient management of burn wounds. Iran J Med Sci 34:61–64Google Scholar
  10. 10.
    Rao TV, Chandrasekharam V (1981) Use of dry human bovine amnion as a biological dressing. Arch Surg 116:891–896PubMedCrossRefGoogle Scholar
  11. 11.
    Colocho G, Graham WP, Greene AE et al (1974) Human amniotic membrane as a physiologic wound dressing. Arch Surg 109:370–373PubMedCrossRefGoogle Scholar
  12. 12.
    Burgos H, Sergeant R (1983) Lyophilized human amniotic membranes used in reconstruction of the ear. J R Soc Med 76:433PubMedCentralPubMedGoogle Scholar
  13. 13.
    Adly O, Moghazy A, Abbas A et al (2010) Assessment of amniotic and polyurethane membrane dressings in the treatment of burns. Burns 36:703–710PubMedCrossRefGoogle Scholar
  14. 14.
    Singh R, Chacharkar M (2011) Dried gamma-irradiated amniotic membrane as dressing in burn wound care. J Tissue Viability 20:49–54PubMedCrossRefGoogle Scholar
  15. 15.
    Halim AS, Khoo TL, Yussof SJM (2010) Biologic and synthetic skin substitutes: an overview. Indian J Plast Surg 43:23–28CrossRefGoogle Scholar
  16. 16.
    Trelford J, Trelford-Sauder M (1979) The amnion in surgery, past and present. Am J Obstet Gynecol 134:833–845PubMedGoogle Scholar
  17. 17.
    Matthews R, Faulk W, Bennett J (1982) A review of the role of amniotic membranes in surgical practice. Obstet Gynecol Ann 11:31–58Google Scholar
  18. 18.
    Talmi Y, Finkelstein Y, Zohar Y (1990) Use of human amniotic membrane as a biologic dressing. Eur J Plast Surg 13:160–162CrossRefGoogle Scholar
  19. 19.
    Unger M, Roberts M (1976) Lyophilized amniotic membranes on graft donor sites. Br J Plast Surg 29:99–101PubMedCrossRefGoogle Scholar
  20. 20.
    Mostaque A, Rahman K (2011) Comparisons of the effects of biological membrane (amnion) and silver sulfadiazine in the management of burn wounds in children. J Burn Care Res 32:200–209PubMedCrossRefGoogle Scholar
  21. 21.
    Bujang-Safawi E, Halim A, Khoo T, Dorai A (2010) Dried irradiated human amniotic membrane as a biological dressing for facial burns -a 7-year case series. Burns 36:876–882PubMedCrossRefGoogle Scholar
  22. 22.
    Mohammadi AA, Mohammadi MK (2011) How does human amniotic membrane help major burn patients who need skin grafting: new experiences. In: Spear M (ed) Ski. grafts – Indic. Appl. Curr. Res. In Tech Europe, Rijeka, Croatia pp 265–276Google Scholar
  23. 23.
    Mohammadi AA, Johari HG, Eskandari S (2013) Effect of amniotic membrane on graft take in extremity burns. Burns 39:1137–1141PubMedCrossRefGoogle Scholar
  24. 24.
    Barnea Y, Amir A, Leshem D et al (2004) Clinical comparative study of aquacel and paraffin gauze dressing for split-skin donor site treatment. Ann Plast Surg 53:132–136PubMedCrossRefGoogle Scholar
  25. 25.
    Innes ME, Umraw N, Fish JS et al (2001) The use of silver coated dressings on donor site wounds: a prospective, controlled matched pair study. Burns 27:621–627PubMedCrossRefGoogle Scholar
  26. 26.
    Losada F, García-Luna PP, Gómez-Cía T et al (2002) Effects of human recombinant growth hormone on donor-site healing in burned adults. World J Surg 26:2–8PubMedCrossRefGoogle Scholar
  27. 27.
    Singh R, Kumar A, Singh D, Malviya A (2013) Use of gamma-irradiated amniotic membrane for the healing of split skin graft donor site. Tissue Eng Regen Med 10:110–114. doi: 10.1007/s13770-013-0004-5 CrossRefGoogle Scholar
  28. 28.
    Salehi SH, As’adi K, Mousavi SJ, Shoar S (2013) Evaluation of amniotic membrane effectiveness in skin graft donor site dressing in burn patients. Indian J Surg. doi: 10.1007/s12262-013-0864-x. http://link.springer.com/search?query=Evaluation+of+Amniotic+Membrane+Effectiveness+in+Skin+Graft+Donor+Site+Dressing+in+Burn+Patients&search-within=Journal&facet-journal-id=12262#page-2. Published online 31 Jan 2013
  29. 29.
    Fraser JF, Cuttle L, Kempf M et al (2009) A randomised controlled trial of amniotic membrane in the treatment of a standardised burn injury in the merino lamb. Burns 35:998–1003PubMedCrossRefGoogle Scholar
  30. 30.
    Kirschbaum S, Hernandez H (1963) Use of amnion in extensive burns. In: 3rd International Congress in Plastic Surgery. Excerpta Medica, AmsterdamGoogle Scholar
  31. 31.
    Pigeon J (1960) Treatment of second-degree burns with amniotic membranes. Can Med Assoc J 83:844–845PubMedCentralPubMedGoogle Scholar
  32. 32.
    Dino B, Eufemio G, De Villa M (1966) Human amnion: the establishment of an amnion bank and its practical application in surgery. J Philipp Med Assoc 42:357–366PubMedGoogle Scholar
  33. 33.
    Sharma S, Bagree M, Bhat A et al (1985) Amniotic membrane is an affective burn dressing material. Jpn J Surg 15:140–143PubMedCrossRefGoogle Scholar
  34. 34.
    Burleson R, Eiseman B (1972) Nature of the bond between partial-thickness skin and wound granulations. Surgery 72:315–322PubMedGoogle Scholar
  35. 35.
    Niknejad H, Peirovi H, Jorjani M et al (2008) Properties of the amniotic membrane for potential use in tissue engineering. Eur Cell Mater 15:88–99PubMedGoogle Scholar
  36. 36.
    Gump F, Kinney J (1970) Caloric and fluid losses through the burn wound. Surg Clin N Am 50:1235–1248PubMedGoogle Scholar
  37. 37.
    Ghalambor A, Pipilzadeh MH, Khodadadi A (2000) The amniotic membrane: a suitable biological dressing to prevent infection in thermal burns. Med J Islam Acad Sci 13:115–118Google Scholar
  38. 38.
    Walker AB, Cooney DR, Allen JE (1977) Use of fresh amnion as a burn dressing. J Pediatr Surg 12:391–395PubMedCrossRefGoogle Scholar
  39. 39.
    Miller T, Switzer W, Foley F, Moncrief J (1967) Early homografting of second degree burns. Plast Reconstr Surg 40:117–125PubMedCrossRefGoogle Scholar
  40. 40.
    Robson M, Krizek T, Koss N, Samburg J (1973) Amniotic membranes as a temporary wound dressing. Surg Gynecol Obstet 136:904–906PubMedGoogle Scholar
  41. 41.
    Bose B (1979) Burn wound dressing with human amniotic membrane. Ann R Coll Surg Engl 61:444–447PubMedCentralPubMedGoogle Scholar
  42. 42.
    Bapat C, Kothary P (1974) Preliminary report on acceleration of wound healing by amnion membrane graft. Indian J Med Res 62:1342–1346PubMedGoogle Scholar
  43. 43.
    Kim JS, Kim JC, Na BK et al (2000) Amniotic membrane patching promotes healing and inhibits proteinase activity on wound healing following acute corneal alkali burn. Exp Eye Res 70:329–337PubMedCrossRefGoogle Scholar
  44. 44.
    Faulk WP, Stevens PJ, Burgos H et al (1980) Human amnion as an adjunct in wound healing. Lancet 315:1156–1158CrossRefGoogle Scholar
  45. 45.
    Trelford J, Hanson F, Anderson D (1973) Amniotic membrane as a living surgical dressing in human patients. Oncology 28:358–364PubMedCrossRefGoogle Scholar
  46. 46.
    Gruss JS, Jirsch DW (1978) Human amniotic membrane: a versatile wound dressing. Can Med Assoc J 118:1237–1246PubMedCentralPubMedGoogle Scholar
  47. 47.
    Saymen DG, Nathan P, Holder IA et al (1973) Control of surface wound infection: skin versus synthetic grafts. Appl Microbiol 25:921–934PubMedCentralPubMedGoogle Scholar
  48. 48.
    Burleson R, Eiseman B (1973) Mechanisms of antibacterial effect of biologic dressings. Ann Surg 177:181–186PubMedCentralPubMedCrossRefGoogle Scholar
  49. 49.
    Galask R, Snyder I (1970) Antimicrobial factors in amniotic fluid. Am J Obstet Gynecol 106:59–65PubMedGoogle Scholar
  50. 50.
    Sachs B, Stern C (1979) Activity and characterization of a low molecular fraction present in human amniotic fluid with broad spectrum antibacterial activity. Br J Obstet Gynaecol 86:81–86PubMedCrossRefGoogle Scholar
  51. 51.
    Faulk W, Galbraith GM (1979) Trophoblast transferrin and transferrin receptors in the host-parasite relationship of human pregnancy. Proc R Soc B Biol Sci 204:83–97CrossRefGoogle Scholar
  52. 52.
    McIntyre JA, Faulk WP (1979) Antigens of human trophoblast: effects of heterologous anti-trophoblast sera on lymphocyte responses in vitro. J Exp Med 149:824–836PubMedCrossRefGoogle Scholar
  53. 53.
    Akle C, Adinolfi M, Welsh K et al (1981) Immunogenicity of human amniotic epithelial cells after transplantation into volunteers. Lancet 2:1003–1005PubMedCrossRefGoogle Scholar
  54. 54.
    Dziedzic-Goclawska A (2000) The application of ionizing radiation to sterilise connective tissue allografts. In: Nather A, Yusof N, Hilmy N (eds) Radiation in tissue banking. World Scientific, Singapore, p 586Google Scholar
  55. 55.
    Singh R, Purohit S, Chacharkar M et al (2007) Microbiological safety and clinical efficacy of radiation sterilized amniotic membranes for treatment of second-degree burns. Burns 33:505–510PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.Department of Reconstructive Sciences, School of Medical SciencesHealth Campus, Universiti Sains MalaysiaKubang KerianMalaysia
  2. 2.Department of SurgeryUniversiti Malaysia SarawakKuchingMalaysia

Personalised recommendations