Clinical Aspects of Urea Transporters

  • Jianhua Ran
  • Hongkai Wang
  • Tinghai Hu
Part of the Subcellular Biochemistry book series (SCBI, volume 73)


Jk antigens, which were identified as urea transporter B (UT-B) in the plasma membrane of erythrocytes, and which determine the Kidd blood type in humans, are involved in transfusion medicine, and even in organ transplantation. The Jk(a-b-) blood type is a consequence of a silent Slc14A1 gene caused by various mutations related to lineage. In addition, the specific mutations related to hypertension and metabolic syndrome cannot be ignored. Genome-wide association studies established Slc14A1 as a related gene of bladder cancer and some genotypes are associated with higher morbidity. This chapter aims to introduce the clinical significance of urea transporters.


Urea Urea transporter Jk antigens Mutations 



This work was supported by NSFC grants 30500171, Scientific and Technological Research Program of Chongqing Municipal Education Commission KJ120330 and Scientific and Technological Research Program of Chongqing Yuzhongqu Scientific and Technological Commission 20120202 to JHR.


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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Department of Anatomy and Neuroscience Center, Basic Medical CollegeChongqing Medical UniversityChongqingChina
  2. 2.Department of Nephrology, The Second Affiliated HospitalChongqing Medical UniversityChongqingChina

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