Epilepsy Comorbidities: How Can Animal Models Help?

  • Carl E. Stafstrom
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 813)


An epilepsy comorbidity is a condition or disorder that occurs at a frequency greater than chance in a person with epilepsy. Examples of common epilepsy comorbidities are depression, anxiety, and intellectual disability. Epilepsy comorbidities can be quite disabling, sometimes affecting a patient’s quality of life to a greater extent than seizures. Animal models offer the opportunity to explore shared pathophysiological mechanisms, therapeutic options, and consequences of both the epilepsy syndrome and a given comorbidity. In this chapter, depression is used as an example of how animal models can inform translational questions about epilepsy comorbidities.


Epilepsy Comorbidity Depression Animal models 


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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Departments of Neurology and PediatricsUniversity of WisconsinMadisonUSA

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