Are Alterations in Transmitter Receptor and Ion Channel Expression Responsible for Epilepsies?

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 813)


Neuronal voltage-gated ion channels and ligand-gated synaptic receptors play a critical role in maintaining the delicate balance between neuronal excitation and inhibition within neuronal networks in the brain. Changes in expression of voltage-gated ion channels, in particular sodium, hyperpolarization-activated cyclic nucleotide-gated (HCN) and calcium channels, and ligand-gated synaptic receptors, in particular GABA and glutamate receptors, have been reported in many types of both genetic and acquired epilepsies, in animal models and in humans. In this chapter we review these and discuss the potential pathogenic role they may play in the epilepsies.


Genetic generalized epilepsy Acquired epilepsy Voltage-gated ion channels Ligand-gated ion channels Animal models of epilepsy 


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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Department of Medicine, The Royal Melbourne HospitalThe University of MelbourneParkvilleAustralia
  2. 2.The Nencki Institute of Experimental BiologyPolish Academy of SciencesWarsawPoland
  3. 3.Department of Neurobiology, A.I. Virtanen Institute for Molecular SciencesUniversity of Eastern FinlandKuopioFinland
  4. 4.Department of NeurologyKuopio University HospitalKuopioFinland

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