Resident Cardiac Progenitor Cells

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Abstract

Resident cardiac stem/progenitor cells are implicated in cell replacement, repair and maintenance of the myocardium. These cells are already committed to a specific cardiomyogenic pathway. Stimulation of these cells in injured hearts can open new options in cardiovascular regenerative medicine, and advance our approach to patients with end-stage heart failure. This chapter reviews some of the recent discoveries in the field of resident cardiac stem/progenitor cells, focusing first on human cardiac stem cell characteristics and reparative potential, including the concept of myocardial regeneration. In addition, we will briefly review recent clinical trials, controversies and unresolved issues.

Keywords

Cardiac progenitor cells Clinical stem cell trials Intermyocardial injection Repair of myocardium Resident cardiac stem cells Self-renewal of cardiomyocytes Stem cell transplantation 
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Notes

Source of Funding

This work was supported by an EC grant (FP7 HEALTH-F2–2009-222995 INELPY) to JL.

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Tamman Cardiovascular Research Institute, Leviev Heart CenterSheba Medical CenterTel-HashomerIsrael
  2. 2.Tamman Cardiovascular Research Institute, Leviev Heart CenterTel-Aviv UniversityTel-HashomerIsrael
  3. 3.Neufeld Cardiac Research Institute, Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael

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