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Translational Models of Dopaminergic Mechanisms for Motivational Deficits in Anhedonic Patients

  • Michael T. Treadway
  • David H. Zald
Chapter

Abstract

Anhedonia is a core symptom of multiple psychiatric disorders, the neurobiological substrates of remain poorly understood. Despite significant preclinical advances in the identification of specific sub-components of reward processing, clinical definitions of anhedonia primarily emphasize reductions in pleasure and positive emotionality, while impaired motivation is often neglected. Here, we review recent evidence suggesting that motivational deficits may reflect an important dimension of symptomatology that is discrete from traditional definitions of anhedonia in terms of both behavior and pathophysiology. In summarizing this work, we highlight the use of translational models such as effort-based decision-making as important tools for elucidating the biological basis of motivational deficits in clinical populations. Finally, we touch on some of the implications of this work for improving diagnosis and treatment.

Keywords

Anhedonia Motivation Effort Depression Schizophrenia Dopamine Ventral striatum Insula 

Abbreviations

MDD

Major Depressive Disorder

DA

Dopamine

VS

Ventral striatum

BDI

Beck Depression Inventory

SHAPS

Snaith-Hamilton Pleasure Scale

FCPS

Fawcett-Clark Pleasure Scale

SANS

Scale of Negative Symptoms

TEPS

Temporal Experience of Pleasure Scale

EEfRT

Effort Expenditure for Rewards Task

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Center for Depression, Anxiety and Stress ResearchMcLean Hospital/Harvard Medical SchoolBelmontUSA
  2. 2.Department of PsychologyEmory UniversityAtlantaUSA
  3. 3.Department of PsychologyVanderbilt UniversityNashvilleUSA
  4. 4.Department of PsychiatryVanderbilt UniversityNashvilleUSA

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