Prime Time for the Drosophila JAK/STAT Pathway

  • Erika A. Bach
  • Norbert Perrimon
Chapter

Abstract

The JAK/STAT pathway is an evolutionarily conserved phosphotyrosine driven pathway that has been identified in many metazoans. In Drosophila, as in mammals, this pathway is used in diverse cellular processes. Studies in Drosophila have identified a requirement for this pathway in processes as diverse as sex determination, embryonic segmentation, cell movement, planar polarity, hematopoiesis, cell differentiation and proliferation. Future studies in Drosophila have much to contribute to our overall understanding of the JAK/STAT pathway in metazoans. Many Drosophila paradigms are now available that will help in identifying the downstream targets regulated by this pathway, and how it interacts with others to regulate various biological functions. Furthermore, because of its simplicity, with only one JAK and STAT, studies of this pathway are easier in flies than in vertebrates. In this review we discuss the components, roles and future directions of studies on the Drosophila JAK/STAT pathway.

Key words

JAK/STAT Drosophila development chromatin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Hombria, J. C., and Brown, S. (2002) Curr Biol 12, R569–575PubMedCrossRefGoogle Scholar
  2. 2.
    Hou, S. X., Zheng, Z., Chen, X., and Perrimon, N. (2002) Dev Cell 3, 765–778PubMedCrossRefGoogle Scholar
  3. 3.
    Harrison, D. A., McCoon, P. E., Binari, R., Gilman, M., and Perrimon, N. (1998) Genes Dev 12, 3252–3263PubMedCrossRefGoogle Scholar
  4. 4.
    Zeidler, M. P., Perrimon, N., and Strutt, D. I. (1999) Genes Dev 13, 1342–1353PubMedCrossRefGoogle Scholar
  5. 5.
    Tulina, N., and Matunis, E. (2001) Science 294, 2546–2549PubMedCrossRefGoogle Scholar
  6. 6.
    Agaisse, H., Petersen, U.-M., Boutros, M., Mathey-Prevot, B., and Perrimon, N. (submitted)Google Scholar
  7. 7.
    Brown, S., Hu, N., and Hombria, J. C. (2001) Curr Biol 11, 1700–1705PubMedCrossRefGoogle Scholar
  8. 8.
    Chen, H. W., Chen, X., Oh, S. W., Marinissen, M. J., Gutkind, J. S., and Hou, S. X. (2002) Genes Dev 16, 388–398PubMedCrossRefGoogle Scholar
  9. 9.
    Binari, R., and Perrimon, N. (1994) Genes Dev 8, 300–312PubMedCrossRefGoogle Scholar
  10. 10.
    Huang, L. J., Constantinescu, S. N., and Lodish, H. F. (2001) Mol Cell 8, 1327–1338PubMedCrossRefGoogle Scholar
  11. 11.
    Harrison, D. A., Binari, R., Nahreini, T. S., Gilman, M., and Perrimon, N. (1995) EMBO J 14, 2857–2865PubMedGoogle Scholar
  12. 12.
    Luo, H., Hanratty, W. P., and Dearolf, C. R. (1995) EMBO J 14, 1412–1420PubMedGoogle Scholar
  13. 13.
    Hou, X. S., Melnick, M. B., and Perrimon, N. (1996) Cell 84, 411–419PubMedCrossRefGoogle Scholar
  14. 14.
    Yan, R., Small, S., Desplan, C., Dearolf, C. R., and Darnell, J. E., Jr. (1996) Cell 84, 421–430PubMedCrossRefGoogle Scholar
  15. 15.
    Henriksen, M. A., Betz, A., Fuccillo, M. V., and Darnell, J. E., Jr. (2002) Genes Dev 16, 2379–2389PubMedCrossRefGoogle Scholar
  16. 16.
    Chung, C. D., Liao, J., Liu, B., Rao, X., Jay, P., Berta, P., and Shuai, K. (1997) Science 278, 1803–1805PubMedCrossRefGoogle Scholar
  17. 17.
    Mohr, S. E., and Boswell, R. E. (1999) Gene 229, 109–116PubMedCrossRefGoogle Scholar
  18. 18.
    Hari, K. L., Cook, K. R., and Karpen, G. H. (2001) Genes Dev 15, 1334–1348PubMedCrossRefGoogle Scholar
  19. 19.
    Betz, A., Lampen, N., Martinek, S., Young, M. W., and Darnell, J. E., Jr. (200 1) Proc Natl Acad Sci USA 98, 9563–9568Google Scholar
  20. 20.
    Starr, R., and Hilton, D. J. (1999) Bioessays 21, 47–52PubMedCrossRefGoogle Scholar
  21. 21.
    Zeidler, M. P., Bach, E. A., and Perrimon, N. (2000) Oncogene 19, 2598–2606PubMedCrossRefGoogle Scholar
  22. 22.
    Callus, B. A., and Mathey-Prevot, B. (2002) Oncogene 21, 4812–4821PubMedCrossRefGoogle Scholar
  23. 23.
    Karsten, P., Hader, S., and Zeidler, M. P. (2002) Mech Dev 117, 343–346PubMedCrossRefGoogle Scholar
  24. 24.
    Zeidler, M. P., and Perrimon, N. (2000) Curr Biol 10, R682–684PubMedCrossRefGoogle Scholar
  25. 25.
    Sefton, L., Timmer, J. R., Zhang, Y., Beranger, F., and Cline, T. W. (2000) Nature 405, 970–973PubMedCrossRefGoogle Scholar
  26. 26.
    Jinks, T. M., Polydorides, A. D., Calhoun, G., and Schedl, P. (2000) Mol Cell 5, 581–587PubMedCrossRefGoogle Scholar
  27. 27.
    Spradling, A. C., de Cuevas, M., Drummond-Barbosa, D., Keyes, L., Lilly, M., Pepling, M., and Xie, T. (1997) Cold Spring Harb Symp Quant Biol 62, 25–34PubMedCrossRefGoogle Scholar
  28. 28.
    Kiger, A. A., and Fuller, M. T. (2001) in Stem Cell Biology (Marshak, D. R., Gardner, R. L., and Gottlieb, D., eds.), pp. 149–187, Cold Spring Harbor Laboratory PressGoogle Scholar
  29. 29.
    Xie, T., and Spradling, A. C. (1998) Cell 94, 251–260PubMedCrossRefGoogle Scholar
  30. 30.
    Kiger, A. A., Jones, D. L., Schulz, C., Rogers, M. B., and Fuller, M. T. (2001) Science 294, 2542–2545PubMedCrossRefGoogle Scholar
  31. 31.
    Roth, S. (200 1) Curr Biol 11, R779–781Google Scholar
  32. 32.
    Tworoger, M., Larkin, M. K., Bryant, Z., and Ruohola-Baker, H. (1999) Genetics 151, 739–748PubMedGoogle Scholar
  33. 33.
    McGregor, J. R., Xi, R., and Harrison, D. A. (2002) Development 129, 705–717PubMedGoogle Scholar
  34. 34.
    Baksa, K., Parke, T., Dobens, L. L., and Dearolf, C. R. (2002) Dev Biol 243, 166–175PubMedCrossRefGoogle Scholar
  35. 35.
    Ghiglione, C., Devergne, O., Georgenthum, E., Carballes, F., Medioni, C., Cerezo, D., and Noselli, S. (2002) Development 129, 5437–5447PubMedCrossRefGoogle Scholar
  36. 36.
    Xi, R., McGregor, J. R., and Harrison, D. A. (2003) Dev Cell 4, 167–177PubMedCrossRefGoogle Scholar
  37. 37.
    Silver, D. L., and Montell, D. J. (2001) Cell 107, 831–841PubMedCrossRefGoogle Scholar
  38. 38.
    Beccari, S., Teixeira, L., and Rorth, P. (2002) Mech Dev 111, 115–123PubMedCrossRefGoogle Scholar
  39. 39.
    Montell, D. J., Rorth, P., and Spradling, A. C. (1992) Cell 71, 51–62PubMedCrossRefGoogle Scholar
  40. 40.
    Chen, X., Oh, S. W., Zheng, Z., Chen, H. W., Shin, H. H., and Hou, S. X. (2003) Dev Cell 4, 179–190PubMedCrossRefGoogle Scholar
  41. 41.
    Sherr, C. J., and Roberts, J. M. (1999) Genes Dev 13, 1501–1512PubMedCrossRefGoogle Scholar
  42. 42.
    Johansen, K. A., Iwaki, D. D., and Lengyel, J. A. (2003) Development 130, 135–145PubMedCrossRefGoogle Scholar
  43. 43.
    Lengyel, J. A., and Iwaki, D. D. (2002) Dev Biol 243, 1–19PubMedCrossRefGoogle Scholar
  44. 44.
    Yamashita, S., Miyagi, C., Carmany-Rapey,m A., Shimizu, T., Fujii, R., Schier, A. F., and Hirano, T. (2002) Dev Cell 2, 363–375Google Scholar
  45. 45.
    Tepass, U., Fessler, L. I., Aziz, A., and Hartenstein, V. (1994) Development 120, 1829–1837PubMedGoogle Scholar
  46. 46.
    Lebestky, T., Chang, T., Hartenstein, V., and Banerjee, U. (2000) Science 288, 146–149PubMedCrossRefGoogle Scholar
  47. 47.
    Franc, N. C., Dimarcq, J. L., Lagueux, M., Hoffmann, J., and Ezekowitz, R. A. (1996) Immunity 4, 431–443PubMedCrossRefGoogle Scholar
  48. 48.
    Bach, E. A., and Perrimon, N. (200 1) in The JAK-STAT Pathway in Hematopoiesis and Disease (Ward, A., ed), pp. 112–126, Landes Bioscience and Kluwer Academic/Plenum, New YorkGoogle Scholar
  49. 49.
    Lanot, R., Zachary, D., Holder, F., and Meister, M. (200 1) Dev Biol 230, 243–257Google Scholar
  50. 50.
    Myrick, K. V., and Dearolf, C. R. (2000) Gene 244, 119–125PubMedCrossRefGoogle Scholar
  51. 51.
    Lagueux, M., Perrodou, E., Levashina, E. A., Capovilla, M., and Hoffmann, J. A. (2000) Proc Natl Acad Sci USA 97, 11427–11432PubMedCrossRefGoogle Scholar
  52. 52.
    Hoffmann, J. A., and Reichhart, J. M. (2002) Nat Immunol3, 121–126Google Scholar
  53. 53.
    Barillas-Mury, C., Han, Y. S., Seeley, D., and Kafatos, F. C. (1999) EMBO J 18, 959–967PubMedCrossRefGoogle Scholar
  54. 54.
    Wolff, T., and Ready, D. R. (1993) in The Development of Drosophila melanogaster (Martinez Arias, M., and Bate, M., eds.) Vol. 2, pp. 1277–1325, 2 vols., Cold Spring Harbor Laboratory Press, Plainview, New YorkGoogle Scholar
  55. 55.
    Luo, H., Asha, H., Kockel, L., Parke, T., Mlodzik, M., and Dearolf, C. R. (1999) Dev Biol 213, 432–441PubMedCrossRefGoogle Scholar
  56. 56.
    Treisman, J. E., and Heberlein, U. (1998) in Current Topics in Developmental Biology Vol. 39, pp. 119–158, Academic PressGoogle Scholar
  57. 57.
    Bach, E. A., Vincent, S., Zeidler, M. P., and Perrimon, N. Genetics In pressGoogle Scholar
  58. 58.
    Datar, S. A., Jacobs, H. W., de la Cruz, A. F., Lehner, C. F., and Edgar, B. A. (2000) EMBO J 19, 4543–4554PubMedCrossRefGoogle Scholar
  59. 59.
    Levy, D. E., and Darnell, J. E., Jr. (2002) Nat Rev Mol Cell Biol 3, 651–662PubMedCrossRefGoogle Scholar
  60. 60.
    Kwon, E. J., Park, H. S., Kim, Y. S., Oh, E. J., Nishida, Y., Matsukage, A., Yoo, M. A., and Yamaguchi, M. (2000) J Biol Chem 275, 19824–19830PubMedCrossRefGoogle Scholar
  61. 61.
    Badenhorst, P., Voas, M., Rebay, I., and Wu, C. (2002) Genes Dev 16, 3186–3198PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2003

Authors and Affiliations

  • Erika A. Bach
    • 1
    • 2
  • Norbert Perrimon
    • 1
    • 2
  1. 1.Department of PharmacologyNew York University School of MedicineNew YorkUSA
  2. 2.Department of Genetics, Howard Hughes Medical InstituteHarvard Medical SchoolBostonUSA

Personalised recommendations