Chapter

Signal Transducers and Activators of Transcription (STATs)

pp 87-104

Prime Time for the Drosophila JAK/STAT Pathway

  • Erika A. BachAffiliated withDepartment of Pharmacology, New York University School of MedicineDepartment of Genetics, Howard Hughes Medical Institute, Harvard Medical School
  • , Norbert PerrimonAffiliated withDepartment of Pharmacology, New York University School of MedicineDepartment of Genetics, Howard Hughes Medical Institute, Harvard Medical School

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Abstract

The JAK/STAT pathway is an evolutionarily conserved phosphotyrosine driven pathway that has been identified in many metazoans. In Drosophila, as in mammals, this pathway is used in diverse cellular processes. Studies in Drosophila have identified a requirement for this pathway in processes as diverse as sex determination, embryonic segmentation, cell movement, planar polarity, hematopoiesis, cell differentiation and proliferation. Future studies in Drosophila have much to contribute to our overall understanding of the JAK/STAT pathway in metazoans. Many Drosophila paradigms are now available that will help in identifying the downstream targets regulated by this pathway, and how it interacts with others to regulate various biological functions. Furthermore, because of its simplicity, with only one JAK and STAT, studies of this pathway are easier in flies than in vertebrates. In this review we discuss the components, roles and future directions of studies on the Drosophila JAK/STAT pathway.

Key words

JAK/STAT Drosophila development chromatin