Prime Time for the Drosophila JAK/STAT Pathway

  • Erika A. Bach
  • Norbert Perrimon


The JAK/STAT pathway is an evolutionarily conserved phosphotyrosine driven pathway that has been identified in many metazoans. In Drosophila, as in mammals, this pathway is used in diverse cellular processes. Studies in Drosophila have identified a requirement for this pathway in processes as diverse as sex determination, embryonic segmentation, cell movement, planar polarity, hematopoiesis, cell differentiation and proliferation. Future studies in Drosophila have much to contribute to our overall understanding of the JAK/STAT pathway in metazoans. Many Drosophila paradigms are now available that will help in identifying the downstream targets regulated by this pathway, and how it interacts with others to regulate various biological functions. Furthermore, because of its simplicity, with only one JAK and STAT, studies of this pathway are easier in flies than in vertebrates. In this review we discuss the components, roles and future directions of studies on the Drosophila JAK/STAT pathway.

Key words

JAK/STAT Drosophila development chromatin 


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Copyright information

© Springer Science+Business Media Dordrecht 2003

Authors and Affiliations

  • Erika A. Bach
    • 1
    • 2
  • Norbert Perrimon
    • 1
    • 2
  1. 1.Department of PharmacologyNew York University School of MedicineNew YorkUSA
  2. 2.Department of Genetics, Howard Hughes Medical InstituteHarvard Medical SchoolBostonUSA

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