Transfection with HSV DNA fragments and DNA from HSV transformed cells

  • G. Darby
  • K. F. Bastow
  • A. C. Minson
Chapter
Part of the Developments in Molecular Virology book series (DMVI, volume 1)

Abstract

Herpes simplex (HSV) possesses a gene coding for the enzyme thymidine kinase (TK). The primary role of this enzyme in the infected cell is the phosphorylation of thymidine to the monophosphate, although it has recently become apparent that the same enzyme is involved in the phosphorylation of TMP to TDP (1). Although experiments in tissue culture have suggested that possession of this enzyme by the virus is a luxury which it can do without (2), more recent studies on the pathogenicity of the virus and TK- mutants have pointed to an important role for the enzyme in animal infections (3,4,5).

Keywords

Thymidine Kinase Virus Sequence Virus Promoter Thymidine Kinase Gene Simplex Virus Thymidine Kinase Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media Dordrecht 1981

Authors and Affiliations

  • G. Darby
  • K. F. Bastow
  • A. C. Minson

There are no affiliations available

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