A Brief History of the Study of Blood Pressure Control
Although the seriousness of high blood pressure in humans was appreciated in the 19th centruy, few studies were undertaken to help understand and correct the problem. Then in the 1900’s the pace quickened with a rapid succession of advances. First one, then many, reliable experimental models came into general use. The renin-angiotensin system was discovered and characterized in considerable detail. The importance of sodium was investigated using dietary manipulation, epidemiological studies, animal models, and lessons from the management of patients with renal disease who were undergoing chronic hemodialysis. Most recently, the subtleties of neural dysfunction have been studied using sensitive assays for catecholamines.
KeywordsRenal Artery Blood Pressure Control Lower Blood Pressure Chronic Hemodialysis Renal Ischemia
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