Pulmonary sequestration

  • N. E. Wiseman
  • R. I. Macpherson
Part of the Advances in the Study of Birth Defects book series (ASBD, volume 6)


Pulmonary sequestration can be defined as an aberrant mass of pulmonary tissue with a systemic arterial blood supply and no normal bronchial connection. The term ‘sequestration’ was introduced by Pryce1 in 1946 and suggests a pulmonary lesion separate from the remainder of the lung both anatomically and functionally. Two major anatomical varieties are recognized — intralobar and extralobar. Both however are part of a broad spectrum of congenital anomalies, with an anomalous blood supply to normal lung at one end, and complex bronchopulmonary-foregut malformations at the other. Thus, the anatomical changes, pathogenesis, and clinical features of pulmonary sequestration can be complex and variable.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Pryce, D. M. (1946). Lower accessory pulmonary artery with intralobar sequestration of lung. J. Pathol. Bacteriol., 58, 457CrossRefPubMedGoogle Scholar
  2. 2.
    Smith, R. A. (1955). Intralobar sequestration of the lung. Thorax, 10, 142CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Carter, R. (1969). Pulmonary sequestration. Ann. Thorac. Surg., 7, 68CrossRefPubMedGoogle Scholar
  4. 4.
    Pendse, P. and Alexander, J. (1972). Pulmonary sequestration; coexisting classic intralobar and extralobar types in a child. J. Thorac. Cardiovasc. Surg., 64, 127PubMedGoogle Scholar
  5. 5.
    Zumbro, G. L. and Treasure, R. L. (1975). Pulmonary sequestration; a broad spectrum of bronchopulmonary foregut malformations. Ann. Thorac. Surg., 20, 161CrossRefPubMedGoogle Scholar
  6. 6.
    Valle, A. R. and White, M. L. (1947). Subdiaphragmatic aberrant pulmonary tissue. Dis. Chest, 13, 63CrossRefPubMedGoogle Scholar
  7. 7.
    Jona, J. Z. and Raffensberger, J. G. (1975). Total sequestration of the right lung. J. Thorac. Cardiovasc. Surg., 69, 361PubMedGoogle Scholar
  8. 8.
    DeParedes, C. G. and Pierce, W. S. (1970). Pulmonary sequestration in infants and children. J. Pediatr. Surg., 5, 136CrossRefPubMedGoogle Scholar
  9. 9.
    White, J. J. and Donahoo, J. S. (1974). Cardiovascular and respiratory manifestations of pulmonary sequestration in childhood. Ann. Thorac. Surg., 18, 286CrossRefPubMedGoogle Scholar
  10. 10.
    Arcomano, J. P. and Azzoni, A. A. (1967). Intralobar pulmonary sequestration and intralobar enteric sequestration associated with vertebral anomalies. J. Thorac. Cardiovasc. Surg., 53, 470PubMedGoogle Scholar
  11. 11.
    Mahour, G. H. and Wooley, M. M. (1971). Association of pulmonary sequestration and duplication of the stomach. Int. Surg., 56, 224PubMedGoogle Scholar
  12. 12.
    Flye, M. W. and Izant, R. J. (1972). Extralobar pulmonary sequestration with esophageal communication and complete duplication of the colon. Surgery, 71, 744PubMedGoogle Scholar
  13. 13.
    Claman, M. A. and Ehrenhaft, J. L. (1960). Bronchopulmonary sequestration. J. Thorac. Cardiovasc. Surg., 39, 531PubMedGoogle Scholar
  14. 14.
    Gerle, R. D. and Jaretzki, A. (1968). Congenital bronchopulmonary-foregut malformations; pulmonary sequestration communicating with the gastrointestinal tract. N. Engl. J. Med., 278, 1413CrossRefGoogle Scholar
  15. 15.
    Macpherson, R. I. and Whytehead, L. (1977). Pseudo Sequestration. J. Can. Assoc. Radiol., 28, 17PubMedGoogle Scholar
  16. 16.
    Roehm, J. O. and June, K. L. (1966). Radiographic features of the scimitar syndrome. Am. J. Roentgenol., 86, 856Google Scholar
  17. 17.
    Vogel, R. (1899). Zwei Fälle von abdominalem Lungengewebe. Arch. Pathol. Anat., 155, 235CrossRefGoogle Scholar
  18. 18.
    Smith, R. A. (1956). Theory of the origin of intralobar sequestration of lung. Thorax, 11, 10CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Boyden, E. A. (1958). Bronchogenic cysts and the theory of intralobar sequestration: new embryologic data. J. Thorac. Surg., 35, 605Google Scholar
  20. 20.
    Cockayne, E. A. and Gladstone, R. J. (1917). A case of accessory lungs associated with hernia through a congenital defect in the diaphragm. J. Anat., 52, 64PubMedPubMedCentralGoogle Scholar
  21. 21.
    Eppinger, H. and Schauenstein, W. (1902). Krankheiten der Lungen. Ergeb. Allg. Pathol., 8, 267Google Scholar
  22. 22.
    Heithoff, B. K. and Shashikant, M. (1976). Bronchopulmonary foregut malformations. A unifying etiological concept. Am. J. Roentgenol., 126, 46CrossRefGoogle Scholar
  23. 23.
    Lewis, E. J. and Murray, R. E. (1968). Pulmonary sequestration with bronchoesophageal fistula. J. Pediatr. Surg., 3, 575CrossRefPubMedGoogle Scholar
  24. 24.
    Moscarella, A. A. and Wylie, R. H. (1968). Congenital communication between esophagus and isolated ectopic pulmonary tissue. J. Thorac. Cardiovasc. Surg., 55, 672PubMedGoogle Scholar
  25. 25.
    Iwai, K. and Shindo, G. (1973). Intralobar pulmonary sequestration, with special reference to developmental pathology. Am. Rev. Resp. Dis., 107, 911PubMedGoogle Scholar
  26. 26.
    Bates, M. (1968). Total unilateral pulmonary sequestration. Thorax, 23, 311CrossRefPubMedPubMedCentralGoogle Scholar
  27. 27.
    Boyden, E. A. and Bill, A. H. (1962). Presumptive origin of a left lower accessory lung from an esophageal diverticulum. Surgery, 52, 323PubMedGoogle Scholar
  28. 28.
    Choplin, R. H. and Siegel, M. J. (1980). Pulmonary sequestration: six unusual presentations. Am. J. Roentgenol., 134, 695CrossRefGoogle Scholar
  29. 29.
    Wiseman, N. E. and Reed, M. H. (1980). Broncho pulmonary arterial malformation occurring in aspergillus lung infection complicating chronic granulomatous disease. J. Pediatr. Surg., (In press)Google Scholar
  30. 30.
    Pinet, F. and Froment, J. C. (1978). Angiography of the thoracic systemic arteries. Radiol. Clin. N. Am., 16, 441PubMedGoogle Scholar
  31. 31.
    Liebow, A. A. and Hales, M. R. (1950). Studies on the lung after ligation of the pulmonary artery. Anatomical changes. Am. J. Pathol., 26, 177PubMedPubMedCentralGoogle Scholar
  32. 32.
    Victor, S. and Lakshmikanthan, C. (1972). Continuous murmur as a sequel of augmented collateral circulation in suppurative lung disease. Chest, 62, 504CrossRefPubMedGoogle Scholar
  33. 33.
    Borrie, J. and Lichter, I. (1963). Intralobar pulmonary sequestration. Br. J. Surg., 50, 623CrossRefPubMedGoogle Scholar
  34. 34.
    Gebauer, P. W. and Mason, C. B. (1959). Intralobar pulmonary sequestration associated with anomalous pulmonary vessels; a nonentity. Chest, 30, 282Google Scholar
  35. 35.
    Bruwer, A. J. and Clagett, O. T. (1954). Intralobar bronchopulmonary sequestration. Am. J. Roentgenol. Radium Ther. Nucl. Med., 71, 751PubMedGoogle Scholar
  36. 36.
    Mannix, E. P. and Haight, C. (1955). Anomalous pulmonary arteries and cystic disease of the lung. Medicine, 34, 193CrossRefPubMedGoogle Scholar
  37. 37.
    Turk, L. N. and Lindskog, G. E. (1961). The importance of angiographic diagnosis in intralobar pulmonary sequestration. J. Thorac. Cardiovasc. Surg., 41, 299PubMedGoogle Scholar
  38. 38.
    Sade, R. M. and Clouse, M. (1974). The spectrum of pulmonary sequestration. Ann. Thorac. Surg., 18, 644CrossRefPubMedGoogle Scholar
  39. 39.
    Seitter, G. and Larson, A. (1974). Pulmonary sequestration. Milit. Med., 139, 899CrossRefGoogle Scholar
  40. 40.
    Reichert, J. R. and Winkler, S. S. (1974). Spontaneous hemorrhage into an extralobar bronchopulmonary sequestration. Radiology, 110, 359CrossRefPubMedGoogle Scholar
  41. 41.
    Zumbro, G. L. and Green, D. C. (1974). Pulmonary sequestration with spontaneous intrapleural hemorrhage. J. Thorac. Cardiovasc. Surg., 68, 673PubMedGoogle Scholar
  42. 42.
    Holstein, P. and Hjelms, E. (1973). Bronchopulmonary sequestration J. Thorac. Cardiovasc. Surg., 65, 462PubMedGoogle Scholar
  43. 43.
    Buntain, W. L. and Isaacs, H. (1974). Lobar emphysema, cystic adenomatoid malformation, pulmonary sequestration, and bronchogenic cysts in infancy and childhood: A clinical group. J. Pediatr. Surg., 9, 85CrossRefPubMedGoogle Scholar
  44. 44.
    Felson, B. (1972). The many faces of pulmonary sequestration. Semin. Roentgenol., 7, 3CrossRefPubMedGoogle Scholar
  45. 45.
    Zelefsky, M. N. and Janis, M. (1971). Intralobar bronchopulmonary sequestration with bronchial communication. Chest, 59, 266CrossRefPubMedGoogle Scholar
  46. 46.
    Halasz, N. A. and Lindskog, G. E. (1962). Esophagobronchial fistula and bronchopulmonary sequestration; report of a case and review of the literature. Ann. Surg., 155, 215CrossRefPubMedPubMedCentralGoogle Scholar
  47. 47.
    Kenney, L. J. and Eyler, W. R. (.1956). Preoperative Diagnosis of Sequestration of the Lung by Aortography. JAMA, 160, 1464CrossRefGoogle Scholar
  48. 48.
    Khalil, K. G. and Kilman, J. W. (1975). Pulmonary Sequestration. J. Thorac. Cardiovasc. Surg., 70, 928PubMedGoogle Scholar
  49. 49.
    Howard, R. (1963). Conservative excision in intralobar sequestration of the lung. Lancet, 2, 1295CrossRefPubMedGoogle Scholar
  50. 50.
    LeRoux, B. T. (1962). Intralobar pulmonary sequestration. Thorax, 17, 77CrossRefGoogle Scholar
  51. 51.
    Buntain, W. L. and Wooley, M. M. (1977). Pulmonary sequestration in children; a 25 year experience. Surgery, 81, 413PubMedGoogle Scholar
  52. 52.
    Douglass, R. (1948). Anomalous pulmonary vessels. J. Thorac. Surg. 17, 712PubMedGoogle Scholar

Copyright information

© MTP Press Limited 1982

Authors and Affiliations

  • N. E. Wiseman
  • R. I. Macpherson

There are no affiliations available

Personalised recommendations