Ethacridine (Rivanol®)—catheter technique in second trimester abortion
At present the mortality and morbidity is higher in mid-trimester than in first trimester abortion, and even if the mid-trimester abortions are few in many countries, there is a need to find safe and effective methods to interrupt a midtrimester pregnancy. Since the early 1960s the most frequently used method for second trimester abortion in Sweden has been the intra- or extra-amniotic instillation of 20% saline. A report by Bengtsson in 1967 of three deaths and a number of serious complications in 6161 saline abortions prompted investigation of other and safer methods. The saline method has gradually been abandoned, and is mainly used in the few pregnancies which are interrupted after the 20th week of gestation as the saline method causes fetal death which is not achieved with prostaglandins or ethacridine—catheter in most cases. Prostaglandins, or the ethacridine—catheter method, are nowadays the most commonly used ways to interrupt a mid-trimester pregnancy in Sweden.
Unable to display preview. Download preview PDF.
- Bengtsson, L. P. (1967). Legal abortion by intrauterine injections. Läkartidningen, 64, 5037Google Scholar
- Fylling, P. and Refsdal, A. (1973). Rivanol induced midtrimester abortion. Arch. Gynaecol., 215, 359Google Scholar
- Ingemanson, C. A. (1979). The ethacridine-catheter method in second-trimester abortion. In Zatuchni, G. I., Sciarra, J. J. and Speidel, J. J. (eds) Pregnancy Termination, Procedures, Safety and New Developments, p. 277. (Hagerstown: Harper & Row)Google Scholar
- Kashiwara, N. and Fujibayashi, Y. (1949). Interruption of pregnancy by extraovular instillation of a solution. Sanfu, Shinpo, 1, 24Google Scholar
- Ölund, A. R. and Bistoletti, P. (1980). Koagulations und fibrinolysesystem bei Rivanol induzierten schwangershaftsabbruch. Zbl. Gynäkol., 102, 507Google Scholar
- Pytel, A. Y., Lopatkin, N. A. and Kuchinsky, I. N. (1963). Acute renal insufficiency associated with intrauterine retromembranous administration of Rivanol for the interruption of pregnancy and its treatment with hemodialysis. Akush. Ginek. (MoSk)., 39, 5Google Scholar
- Sepeika, N. (1934). The action of acriflavine on the uterus. Pharm. Pharmacol., 7, 44Google Scholar