Immunological Manipulations in Renal Allotransplantation

  • Ronald D. Guttmann
Chapter

Abstract

The treatment of patients with end-stage renal disease has evolved into an important branch of medical therapeutics. At the present time there are more than 30 000 patients on chronic haemodialysis, the majority of whom may be awaiting renal transplantation, and since 1962 over 30 000 renal transplants have been carried out around the world. In spite of numerous predictions that this therapeutic effort would be a dismal failure, many patients today owe the significant prolongation of their lives to the important development of means of caring for patients with chronic renal failure and with kidney transplants by refinements in haemodialysis and the use of immunosuppressive medications. Society is demanding more and more that facilities be available for the treatment of chronic renal failure by both the artificial kidney and transplantation, thus the numbers of patients who enter this treatment phase are growing. This is producing large overall economic pressures bolstered by the fact that it is widely accepted that if a kidney transplant is successful the patient is afforded the best type of restoration to a normal quality of life in all aspects. These factors as well as the intellectual challenge should be the major driving forces in various attempts to understand the basic immunological and clinical problems underlying transplantation.

Keywords

Renal Transplantation Acute Rejection Allograft Rejection Renal Allograft Rejection Episode 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© MTP Press Limited 1978

Authors and Affiliations

  • Ronald D. Guttmann
    • 1
  1. 1.Transplant ServiceRoyal Victoria Hospital and McGill UniversityMontrealCanada

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