Fat utilization in critically ill patients

  • Y. A. Carpentier
Chapter

Abstract

Most tissues of the body are able to utilize either glucose or fatty acids for their energy requirements. However, some particular cells (central nervous system, blood cells, etc.) are not capable of oxidizing fatty acids. This can explain why glucose is still often considered as the sole energy substrate to be parenterally administered, exogenous fat being given only to prevent essential fatty acid deficiency.

Keywords

Parenteral Nutrition Total Parenteral Nutrition Essential Fatty Acid Deficiency Lipid System Glucose System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    Askanazi, J., Elwyn, D. H., Silverberg, P. A. et al. (1980). Respiratory distress secondary to a high carbohydrate load of TPN: a case report. Surgery, 87, 596Google Scholar
  2. 2.
    Lowry, S. F. and Brennan, M. F. (1979). Abnormal liver function during parenteral nutrition: relation to infusion excess. J. Surg. Res., 26, 300CrossRefGoogle Scholar
  3. 3.
    Mashima, Y. (1979). Effect of calorie overload on puppy livers during parenteral nutrition. J. Parent. Enter. Nutr., 3, 139CrossRefGoogle Scholar
  4. 4.
    Nordenstrom, J., Jeevanandam, M., Elwyn, D. H. et al. (1981). Glucose loading during total parenteral nutrition increases norepinephrine excretion in trauma and sepsis. Clin. Physiol., 1, 525CrossRefGoogle Scholar
  5. 5.
    Elwyn, D. H., Kinney, J. M., Jeevanandam, M. et al. (1979). Influence of increasing carbohydrate intake on glucose kinetics in injured patients. Ann. Surg., 190, 117CrossRefGoogle Scholar
  6. 6.
    Carpentier, Y. A., Askanazi, J., Elwyn, D. H. et al. (1979). Effect of hypercaloric glucose infusion on lipid metabolism in injury and sepsis. J. Trauma, 19, 649CrossRefGoogle Scholar
  7. 7.
    Carpentier, Y. A., Askanazi, J., Elwyn, D. H. et al. (1980). The effect of carbohydrate intake on the lipolytic rate in depleted patients. Metabolism, 29, 974CrossRefGoogle Scholar
  8. 8.
    Nordenstrom, J., Carpentier, Y. A., Askanazi, J. et al. (1982). Free fatty acid mobilization and oxidation during total parenteral nutrition in trauma and sepsis. (In preparation).Google Scholar
  9. 9.
    Hagenfeldt, L. (1975). Turnover of individual free fatty acids in man. Fed. Proc., 34, 2246Google Scholar
  10. 10.
    Carpentier, Y. A., Nordenstrom, J., Askanazi, J. etal. (1979). Relationship between rates of clearance and oxidation of [14C]Intralipid in surgical patients. Surg. Forum, 30, 72Google Scholar
  11. 11.
    Schoefl, G. I. (1968). The ultrastructure of chylomicron and of the particles in the artificial fat emulsion. Proc. R. Soc. Lond., 169, 147CrossRefGoogle Scholar
  12. 12.
    Robinson, S. F. and Quarfordt, S. H. (1979). Apoproteins in association with Intralipid incubation in rat and human plasma. Lipids, 14, 343CrossRefGoogle Scholar
  13. 13.
    Weinberg, R. B. and Scanu, A. M. (1982). In vitro reciprocal exchange of apoproteins and non-polar lipids between human high density lipoproteins and an artificial triglyceride—phospholipid emulsion quoted by Rosenberg, I. H. and Weinberg, R. B. The composition and metabolism of IV fat emulsions. In Balanced Parenteral Nutrition. (North Chicago, Ill.: Abbott Laboratories 60064) (In press)Google Scholar
  14. 14.
    Erkelens, D. W., Brunzell, J. D. and Bierman, E. L. (1979). Availability of apolipoprotein CII in relation to the maximal removal capacity for an infused triglyceride emulsion in man. Metabolism, 28, 495CrossRefGoogle Scholar
  15. 15.
    Rossner, S. (1974). Studies of an intravenous fat tolerance test. Methodological, experimental and clinical experiences with Intralipid. Acta Med. Scand., 564 (suppl.), 1Google Scholar
  16. 16.
    Nordenstrom, J., Carpentier, Y. A., Askanazi, J. et al. (1982). Metabolic utilization of intravenous fat emulsion during total parenteral nutrition. Ann. Surg. (In press)Google Scholar
  17. 17.
    Askanazi, J., Nordenstrom, J., Rosenbaum, S. H. et al. (1981). Nutrition for the patient with respiratory failure: glucose vs fat. Anesthesiology, 54, 373CrossRefGoogle Scholar
  18. 18.
    Messing, B., Bitoun, A., Galian, A. et al. (1977). La stéatose hépatique au cours de la nutrition parentérale dépend-elle de l’apport calorique glucidique? Gastroenterol. Clin. Biol., 1, 1015Google Scholar
  19. 19.
    Grant, J. P., Cok, C. E., Kleinman, L. M. et al. (1977). Serum hepatic enzyme and bilirubin elevations during parenteral nutrition. Surg. Gynecol. Obstet., 147, 573Google Scholar
  20. 20.
    Sheldon, G. P., Petersen, S. R. and Sanders, R. (1978). Hepatic dysfunction during hyper-alimentation. Arch. Surg., 113, 504CrossRefGoogle Scholar
  21. 21.
    Lindor, K. D., Fleming, C. R., Abrams, A. et al. (1979). Liver function values in adults receiving total parenteral nutrition. J. Am. Med. Assoc., 241, 2398CrossRefGoogle Scholar
  22. 22.
    Carpentier, Y. A. and Van Brandt, M. (1981). Effect of total parenteral nutrition on liver function. Acta Chir. Belg., 2 and 3, 141Google Scholar
  23. 23.
    Harris, J. A. and Benedict, F. G. (1919). Biometric Studies of Basal Metabolism in Man. ( Carnegie Institution of Washington. Publication no 279 )Google Scholar
  24. 24.
    Nordenstrom, J., Jarstrand, C. and Wiernik, A. (1979). Decreased chemotactic and random migration of leukocytes during Intralipid infusion. Am. J. Clin. Nutr., 32, 2416Google Scholar

Copyright information

© MTP Press Limited 1983

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  • Y. A. Carpentier

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