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Relaxation of 13-C Nuclei in Structural Study on Isomers of Cephalosporin Cefuroxime Axetil

  • A. Ejchart
  • A. Zimniak
  • I. Oszczapowicz
  • H. Szatylowicz
Chapter

Abstract

Two diastereomeric forms of antibiotic 1-acetoxyethyl ester of cefuroxime exhibit substantial differences in antimicrobial activity both in vitro and in vivo, as well in solubility, penetration rate through biological membranes and rate of hydrolysis to the parent cefuroxime (free acid) [1]. Structural differences in solutions can be related to different activities of these isomers. Advanced NMR techniques have been applied for investigations presented.

Keywords

Free Acid Penetration Rate Rotational Correlation Time Nuclear Overhauser Effect Cefuroxime AXETIL 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Tejchman, B., Horodecka, M., Jaromińska, M., Oszczapowicz, I. (1995), Acta Polon. Pharm. 52, 477.Google Scholar
  2. 2.
    Neuhaus, D., Williamson, M. (1989), The Nuclear Overhauser Effect in Structural and Conformational Analysis, VCH Publishers.Google Scholar
  3. 3.
    Lipari, G., Szabo, A. (1982), J. Am. Chem. Soc. 104, 4546, 4559.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • A. Ejchart
    • 1
  • A. Zimniak
    • 2
  • I. Oszczapowicz
    • 3
  • H. Szatylowicz
    • 4
  1. 1.A.E. Universitaet BayreuthBayreuthGermany
  2. 2.Medical AcademyWarsawPoland
  3. 3.Institute of Biotechnology and AntibioticsWarsawPoland
  4. 4.Warsaw University of TechnologyWarsawPoland

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