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Lipid-Protein Interactions in Reconstituted Membranes Containing Nicotinic Acetylcholine Receptor

  • J. A. Encinar
  • A. M. Fernández
  • J. A. Poveda
  • J. M. González-Ros
Chapter

Abstract

The nicotinic acetylcholine receptor (AcChR) from Torpedo is a large transmembrane glycoprotein composed of four different polypeptide subunits (α, β, γ and δ) in a 2:1:1:1 stoichiometry. Binding of cholinergic agonists to extracellular domains on the a subunits, causes the formation of a transient cation channel within the protein, responsible for the initiation of postsynaptic membrane depolarization.

Keywords

Phosphatidic Acid Phosphatidic Acid Nicotinic Acetylcholine Receptor Protein Secondary Structure Lipid Mixture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • J. A. Encinar
    • 1
  • A. M. Fernández
    • 1
  • J. A. Poveda
    • 1
  • J. M. González-Ros
    • 1
  1. 1.Department of Neurochemistry and Institute of NeuroscienceUniversity of AlicanteAlicanteSpain

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