The Effect of Resiniferatoxin on Experimental Gastric Ulcer in Rats

  • O. M. E. Abdel-Salam
  • J. Szolcsányi
  • Gy. Mózsik
Chapter

Abstract

Capsaicin-sensitive sensory nerves are involved in modulation of gastric mucosal integrity. The present study aimed to evaluate the effect of the capsaicin analogue, resiniferatoxin (RTX), on gastric mucosal damage produced by different ulcerogenic agents in the rat. Gastric mucosal damage was evoked in pylorus-ligated rats by the administration of intragastric (ig) HC1 (2 ml of 0.6 N), ig ethanol (2 ml of 96% or 50% v/v), ig acidified aspirin (200 mg/kg dissolved in 2 ml of 0.15 HCl), subcutaneous (sc) aspirin (200 mg/kg plus ig 2 ml of 0.15 N HС1) and sc indomethacin (20 mg/kg). Animals were sacrificed at different time intervals after administration of the above ulcerogens, when gastric secretory responses, and the number and severity of mucosal lesions were noted. Intragastric RTX (0.6–2 µg/kg) protected against mucosal injury by 0.6 N HС1 in a dose-dependent manner. Resiniferatoxin at 0.4 µg/ kg prevented mucosal injury by sc indomethacin or sc aspirin in the 4-h pylorus-ligated rat. Resiniferatoxin (0.6 and 1 µg/kg) co-administered with ethanol reduced mucosal injury caused by 50% ethanol. The protective effect of RTX was more marked if the drug was given 15 min prior to ethanol. Resiniferatoxin protected against damage by 96% ethanol if given 15 min prior to challenge, but, when co-administered with 96% ethanol, RTX aggravated the ethanol-induced mucosal damage. Resiniferatoxin by itself did not produce visible gastric mucosal damage in the saline-treated controls. Data indicated that the capsaicin analogue, resiniferatoxin, exerts potent gastroprotective effects in various experimental ulcer models in the rat.

Keywords

resiniferatoxin capsaicin experimental gastric ulcer 
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Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • O. M. E. Abdel-Salam
    • 1
  • J. Szolcsányi
    • 2
  • Gy. Mózsik
    • 1
  1. 1.First Department of MedicineMedical University of PécsPécsHungary
  2. 2.Department of PharmacologyMedical University of PécsPécsHungary

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