X-Ray and Atomic Force Microscopy Structures of Short Chain Amphiphilic Cyclodextrins

  • I. Nicolis
  • A. W. Coleman
  • M. Selkti
  • M. Munoz
  • A. Kasselouri
  • S. Alexandre
  • J.-M. Valleton
  • P. Charpin
  • C. de Rango
Conference paper

Abstract

Cyclodextrins rendered amphiphilic by remarkably short substituents chains have been shown to form stable molecular layers1,2. The results deduced from compression isotherms of Langmuir films at the air-water interface led us to propose the formation of amphiphilic cyclodextrin multilayers and the existence of a highly rigid (solid) system. As the physical characteristics of the Langmuir films might be correlated with bulk solid-state structures, comparative crystallographic studies have been undertaken for α-, β- and γ-cyclodextrins selectively persubstituted at the primary face with very short hydrophobic groups.

Keywords

Compression Isotherm Atomic Force Microscopy Study Molecular Area Monomolecular Layer Langmuir Film 
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References

  1. 1-.
    Nicolis, I., Coleman, A. W., Charpin, P., Villain, F., Zhang, P., Ling, C.C. & Rango C. de (1993). J. Amer. Chem. Soc. 115, 11596–11597 CrossRefGoogle Scholar
  2. 2-.
    Kasselouri, A., Munoz, M., Parrot-Lopez, H. & Coleman, A. W. (1993).Polish J. Chem. 67, 1981–1985.Google Scholar
  3. 3-.
    Alexandre, S., Coleman, A. W., Kasselouri, A. & Valleton J. M. (1996).Thin Solid Films 284–285, 765–768.CrossRefGoogle Scholar
  4. 4-.
    Crystal unit cells. I: P21, Z=4, a=15.539(6), b=31.527(6) c=15.556(5) (Å), β=100.94(3)°; II: P21, Z=4, a=15.714(3), b=15.917(6à, c=30.102(4) (Å), β=90.55(2)°; III: P43212, Z=16, a=b=19.959(3), c= 63.485(14) (Å), data collected with synchrotron radiation, Lure; IV: P21212, Z=4, a=16.819(4), b= 17.154(11), c= 31.368(6) (Å); V: C2, Z=16, a=43.060(8), b=21.936(5), c= 43.466(5) (Å) β= 95.11(1)°; VI: P21, Z=4, a=15.595(11), b=30.409(17), c= 16.637(15) (Å), β= 97.40(6)°; VII: P21, Z=4, a=15.618(17), b=32.28(5), c= 15.637(15)(Å),β= 102.18(9)°.Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1998

Authors and Affiliations

  • I. Nicolis
    • 1
  • A. W. Coleman
    • 2
  • M. Selkti
    • 1
  • M. Munoz
    • 2
  • A. Kasselouri
    • 1
    • 4
  • S. Alexandre
    • 3
  • J.-M. Valleton
    • 3
  • P. Charpin
    • 1
  • C. de Rango
    • 1
  1. 1.ERS128 CNRS, Centre PharmaceutiqueUniversité Paris-SudChâtenay-MalabryFrance
  2. 2.UPR412 CNRSIBCPLyonFrance
  3. 3.URA500 CNRSUniversité de RouenFrance
  4. 4.Laboratoire de Chimie Analytique Centre PharmaceutiqueUniversité Paris-SudChâtenay-MalabryFrance

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