Animal Cell Technology: Basic & Applied Aspects pp 229-233 | Cite as
Effect of Shear Stress on the rCHO Cells
Chapter
Abstract
Effect of shear stress on the endothelial cell has been studied by many workers, but few studies on the effect of shear stress for other cell lines have been reported. We have investigated the effect of shear stress on the rCHO using flat-bed type reactor with non-woven fabric mat and found that therenin productivity was enhanced and the cells attached to the non-woven fabric were aggregated by increasing shear stress. It is therefore considered that shear stress or cell aggregation may affect productivity(1).
Keywords
Shear Stress Inoculum Size Increase Shear Stress Dhfr Gene Human Renin
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References
- 1.E.C. Beuvery et al. (eds.) (1995) Animal cell technology: Developments towards the 21 st Century, 811–815, Kluwer Academic Publishers, Netherlands.Google Scholar
- 2.Suzuki, E. and Ollis, D. F.(1989) Cell cycle model for antibody production kinetics, Biotechnology and Bio engineering 34, 1398–1402.CrossRefGoogle Scholar
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© Springer Science+Business Media Dordrecht 1998