Retinal Pigment Epithelium and Macular Diseases pp 269-273 | Cite as
Propranolol and nimodipine in the treatment of acute and chronic central serous choroidopathy
Chapter
Abstract
The pathogenesis of central serous choroidopathy (CSC) is still unknown. In the past an important role of retinal pigment epithelium had been assumed by many authors1–4. Routinary use of indocyanine green (ICG) angiography has recently demonstrated disturbances in choroidal haemodynamics in most cases of CSC5–7, with late hyperfluorescence noted in the great majority of studies. Such hyperfluorescence has been interpreted as secondary to an increase of blood flow7 or to ischaemic damage of the choriocapillaris5,6. Scheider et al.6 described early hypofluorescence in the same affected areas and speculated that the reduction of blood supply could be a primary stage of CSC pathogenesis. On the basis of these features a pathogenesis of the disease similar to that of migraine could be assumed:
- 1.
Reduction of blood supply;
- 2.
Ischaemic damage to choriocapillaris;
- 3.
Increased protein concentration in the extracellular space;
- 4.
Accumulation of fluid in the extracellular space.
Keywords
Retinal Pigment Epithelium Indocyanine Green Central Serous Chorioretinopathy Serous Retinal Detach Indocyanine Green Angiography
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
- 1.Maumenee, A.E. Symposium: macular diseases. Pathogenesis. Trans Am Acad Ophthalmol Otolaryngol. 1965; 69: 691–699.PubMedGoogle Scholar
- 2.Gass, J.D.M. Pathogenesis of the disciform detachment of the neuroepithelium. II. Idiopathic central serous choroidopathy. Am J Ophthalmol. 1967; 63: 587–615.Google Scholar
- 3.Spitznas, M. Pathogenesis of central serous retinopathy: a new working hypothesis. Graefe’s Arch Clin Exp Ophthalmol. 1986; 224: 321–324.CrossRefGoogle Scholar
- 4.Marmor, M.F. New hypotheses on the pathogenesis and treatment of serous retinal detachment. Graefe’s Arch Clin Exp Ophthalmol. 1988; 226: 548–552.CrossRefGoogle Scholar
- 5.Hayashi, K., Hasegawa, Y., Tokoro, I. Indocyanine green angiography of central serous chorioretinopathy. Int Ophthalmol. 1986; 9: 37–41.PubMedCrossRefGoogle Scholar
- 6.Scheider, A., Nasemann, J.E., Lund, O.E. Fluorescein and indocyanine green angiographies of central serous choroidopathy by scanning laser ophthalmoscopy. Am J Ophthalmol. 1993; 115: 50–56.PubMedGoogle Scholar
- 7.Cardillo Piccolino, F., Borgia, L. Central serous chorioretinopathy and indocyanine green angiography. Retina. 1994; 14: 231–242.CrossRefGoogle Scholar
- 8.Diamond, S., Millstein, E. Current concepts of migraine therapy. J Clin Pharmacol. 1988; 28: 193–199.PubMedGoogle Scholar
- 9.Diamond, S., Solomon, G.D. Pharmacologic treatment of migraine. Ration Drug Ther. 1988; 22: 1–6.PubMedGoogle Scholar
- 10.Spierings, E.L.H. Clinical and experimental evidence for a role of calcium entry blockers in the treatment of migraine. Ann NY Acad Sci. 1988; 522: 676–689.PubMedCrossRefGoogle Scholar
- 11.Greenberg, D.A. Calcium channel antagonists and the treatment of migraine. Clin Neuropharmacol. 1988; 9: 311–328.CrossRefGoogle Scholar
- 12.Potts, A.M. An hypothesis on macular diseases. Trans Am Acad Ophthalmol Otolaryngol. 1966; 70: 1058.PubMedGoogle Scholar
- 13.Yannuzzi, L.A. Type A behavior and central serous chorio-retinopathy. I. Clinical findings. Trans Am Ophthalmol Soc. 1986; 84: 799–845.PubMedGoogle Scholar
- 14.Avci, R., Deutman, A.S. Die Behandlung der zentralen serösen Choroidopathie mit dem Betarezeptorenblocker Metoprolol (Vorläufige Ergebnisse). Klin Monatsbl Augenheilk. 1993; 202: 199–205.CrossRefGoogle Scholar
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