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Fcγ receptor polymorphisms: clinical aspects

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The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity

Part of the book series: Immunology and Medicine Series ((IMME,volume 26))

Abstract

FcγR provide the link between cellular and humoral aspects of the immune cascade. Their structural diversity presents a rich framework within which one can understand how immunoglobulin complexes activate a broad range of cell programs relevant to autoimmunity, cancer and microbial host defence. A fundamental assumption is that different receptor structures have different biological functions. Such differences in structure among FcγR dictate differential signalling potentials and biologic functions and provide a diversity of FcγR within a given individual. Inherited or acquired differences in FcγR structure, expression, or function provide the basis for differences in FcγR function between individuals. Allelic variants of FcγR which confer distinct functional capacities to effector cells are a mechanism for inherited diffe rences in disease susceptibility. Originally, allelic variants of FcγR were identified by phenotypic differences, such as binding to specific mAbs or IgG subclasses. More recently, allele-specific PCR, allele-specific oligomer hybridization of PCR products, SSCP, and direct automated sequencing have provided precise definition of each variant allowing characterization of the corresponding functional phenotype. Clinical significance of allelic polymorphisms of FcγR is the focus of this chapter.

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Authors
  1. J. E. Salmon
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  2. R. P. Kimberly
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Editors and Affiliations

  1. Utrecht University, Utrecht, The Netherlands

    Jan G. J. van de Winkel

  2. Austin Research Institute, Melbourne, Australia

    P. Mark Hogarth

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Salmon, J.E., Kimberly, R.P. (1998). Fcγ receptor polymorphisms: clinical aspects. In: van de Winkel, J.G.J., Hogarth, P.M. (eds) The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity. Immunology and Medicine Series, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5018-7_23

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  • DOI: https://doi.org/10.1007/978-94-011-5018-7_23

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6106-3

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