Regulation of collagen gene expression
The mechanisms responsible for the increased hepatic connective tissue deposition in cirrhosis remain unknown, and there is no established therapy for hepatic fibrosis. Fibrogenesis plays an important role in the accumulation of hepatic connective tissue (Chojkier, 1993). In cirrhotic livers, whatever the etiology, fibrogenesis results in a several-fold increase in collagen content. Collagen types present in normal livers (I, III, IV, V and VI) increase together in hepatic fibrogenesis (Seyer, Hutchenson and Kang, 1977; Rojkind, Rojkind and Cordero-Hernandez, 1983; Clement, Grimaud and Champion, 1986; Martinez-Hernandez, 1986), suggesting a co-ordinated regulation of collagen gene expression.
KeywordsLipid Peroxidation Iron Overload Stellate Cell Hepatic Fibrosis Hepatic Stellate Cell
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- Adams, R.L.P. (1980) Cell culture for biochemists, in Laboratory Techniques in Biochemistry and Molecular Biology (eds T.S. Work and R.H. Burbon), Elsevier/North-Holland, Amsterdam, pp. 35–36.Google Scholar
- Bikle, D.D. (1990) Metabolism and functions of vitamins A, D, and K, in Hepatology: A Textbook of Liver Disease (eds D. Zakim and T. Boyer), WB Saunders, Philadelphia, pp. 182–196.Google Scholar
- Blank, R.S., McQuinn, T.C., Yin, K.C. et al. (1992) Elements of the smooth muscle α-actin promoter requiredin cis for transcriptional activation in smooth muscle. Journal of Biological Chemistry, 267, 984–988.Google Scholar
- Chojkier, M. (1993) Pathogenesis of hepatic fibrosis, in Extracellular Matrix (eds M. Zern and L. Reid), Marcel Dekker Inc., New York, pp. 541–557.Google Scholar
- Christman, M.F., Storz, G. and Ames, B.M. (1989) OxyR, a positive regulator of hydrogen peroxide-inducible genesin Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins. Proceedings of the National Academy of Sciences USA, 86, 3484–3488.CrossRefGoogle Scholar
- Goldberg, L., Martin, L.E. and Batchelor, A. (1962) Biochemical changes in the tissue of animals injected with iron. Biochemical Journal, 83, 291–298.Google Scholar
- Gualdi, R., Casalgrandi, G., Moniosi, G. et al. (1994) Excess iron in hepatocytes is required for activation of collagen I gene during experimental siderosis. Gastroentrology, 107, 1118–1234.Google Scholar
- Guyton, A.C. (1984) Physiology of the Human Body. CBS College Publishing, New York.Google Scholar
- Martinez-Hernandez, A. (1986) The hepatic extracellular matrix. II. Electron immuno-histochemical studies in rats with CCl4-induced cirrhosis. Laboratory Investigation, 53, 166–186.Google Scholar
- Raghow, R., Postlethwaite, A.E., Keski-Oja, J. et al. (1987) Transforming growth factor β increases steady state levels of type I procollagen and fibronectin messenger RNAs post-transcriptionally in cultured human dermal fibroblasts. Journal of Clinical Investigation, 79, 1285–1288.PubMedCrossRefGoogle Scholar
- Schauenstein, E.H., Esterbauer, H. and Zollner, H. (1977) Aldehydes in Biological Systems. Pion Limited, London.Google Scholar
- Spanheimer, R.G. and Peterkofsky, B. (1986) A specific decrease in collagen synthesis in acutely fasted, vitamin C-supplemented guinea pigs. Journal of Biological Chemistry, 260, 3955–3962.Google Scholar