Regulation of collagen gene expression

  • Mario Chojkier


The mechanisms responsible for the increased hepatic connective tissue deposition in cirrhosis remain unknown, and there is no established therapy for hepatic fibrosis. Fibrogenesis plays an important role in the accumulation of hepatic connective tissue (Chojkier, 1993). In cirrhotic livers, whatever the etiology, fibrogenesis results in a several-fold increase in collagen content. Collagen types present in normal livers (I, III, IV, V and VI) increase together in hepatic fibrogenesis (Seyer, Hutchenson and Kang, 1977; Rojkind, Rojkind and Cordero-Hernandez, 1983; Clement, Grimaud and Champion, 1986; Martinez-Hernandez, 1986), suggesting a co-ordinated regulation of collagen gene expression.


Lipid Peroxidation Iron Overload Stellate Cell Hepatic Fibrosis Hepatic Stellate Cell 
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Copyright information

© Springer Science+Business Media Dordrecht 1998

Authors and Affiliations

  • Mario Chojkier
    • 1
  1. 1.Department of Medicine and Center for Molecular GeneticsUniversity of CaliforniaSan DiegoUSA

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