Transcription factors HSF and NF-КB as targets for cytoprotective eicosanoids: a new strategy for therapeutic intervention
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The observation that an increase in temperature of a few degrees above the physiological level induces the synthesis of a small number of proteins in Drosophila salivary glands led to the discovery of a universal protective mechanism which prokaryotic and eukaryotic cells utilize to preserve cellular function and homeostasis1. This complex physiological defence mechanism, known as the heat shock response, involves the rapid induction of a specific set of genes encoding cytoprotective proteins (heat shock protein, HSP). In mammalian cells HSP synthesis is induced in a wide variety of toxic conditions, including extreme temperatures, oxidative stress, exposure to heavy metals or cytotoxic drugs, glucose deprivation and virus infection1. Whereas HSP induction was at first interpreted as a signal for detection of physiological stress, it is now well-documented that HSPs are utilized by the cells in the repair process following different types of injury, to prevent damage resulting from the accumulation and aggregation of non-native proteins2.
KeywordsHeat Shock Protein Heat Shock Response Heat Shock Transcription Factor Sodium Arsenite Human Heat Shock Protein
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