Reactive Oxygen Species as Mediators of Signal Transduction in Cardiovascular Disease

  • Jun-ichi Abe
  • Bradford C. Berk
Chapter
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 233)

Abstract

Cells respond to extracellular stimuli by transmitting intracellular messengers to coordinate appropriate responses. The process that transduces the extracellular message across plasma membranes into the intracellular environment is called signal transduction or cell signaling. Recently, reduction-oxidation (redox) reactions that generate reactive oxygen species (ROS) have gained attention as important chemical processes that regulate signal transduction. Accumulating evidence indicates that excessive ROS may be pathogenic for a wide variety of human diseases.

Keywords

Extracellular Signal Regulate Kinase Compensatory Enlargement Kinase Signal Transduction Pathway Growth Factor Signal Transduction Pyridinyl Imidazole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer Science+Business Media Dordrecht 2000

Authors and Affiliations

  • Jun-ichi Abe
  • Bradford C. Berk

There are no affiliations available

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