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Helicobacter pylori infection: expectations for future therapy

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Helicobacter pylori
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Abstract

Within 12 years of the discovery of Helicobacter pylori and recognition of its importance in ulcer disease, highly effective 1-week regimes for its eradication had become widely used1–3. This rapid progress was achieved with results from a relatively small number of trials that were very pragmatic and often under-powered4, an interesting illustration of the fact that progress can, and usually does, occur in the absence of orthodox research design. As a result, management of H. pylori-associated peptic ulcer has been revolutionized by becoming substantially better and substantially cheaper.

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References

  1. Bazzoli F, Gullini S, Zagari RM et al. Effect of omeprazole and clarithromycin plus tinidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer. Gut. 1995;37(Suppl. 1):5.

    Google Scholar 

  2. Bazzoli F. Italian omeprazole triple therapy — a 1-week regimen. Scand J Gastroenterol. — Suppl. 1996;215:118.

    Article  PubMed  Google Scholar 

  3. Labenz J., Stolte M, Ruhl GH et al. One-week low-dose triple therapy for the eradication of Helicobacter pylori infection. Eur J Gastroenterol Hepatol. 1995;7:9–11.

    PubMed  CAS  Google Scholar 

  4. Sherwood 2000 in preparation

    Google Scholar 

  5. Peterson WL, Ciociola AA, Sykes DL, McSorley DJ, Webb DD and the RBC H. pylori Study Group. Ranitidine bismuth citrate plus clarithromycin is effective for healing duodenal ulcers, eradicating H. pylori and reducing ulcer recurrence. Aliment Pharmacol Ther. 1996;10:251–261.

    Article  PubMed  CAS  Google Scholar 

  6. Goddard AF, Jessa MJ, Barrett DA et al. Effect of omeprazole on the distribution of metronidazole, amoxicillin, and clarithromycin in human gastric juice. Gastroenterology. 1996;111:358–367.

    Article  PubMed  CAS  Google Scholar 

  7. Sherwood PV, Wibaud JI, Goddard AF, Barrett DA, Shaw PN, Spiller RC. Acid secretion determines gastric metronidazole transfer. Gastroenterology. 1999;116:A309.

    Google Scholar 

  8. Houben MHMG, van de Beek D, Hensen EF, De Craen AJM, Rauws EAJ, Tytgat GNJ. A systematic review of Helicobacter pylori eradication therapy — the impact of antimicrobial resistance on eradication rates. Aliment Pharmacol Ther. 1999;13:1047–1055.

    Article  PubMed  CAS  Google Scholar 

  9. Borody TJ, Brandi S, Andews P, Ferch N, Jankiewicz E, Hyland L. Use of high efficacy, lower dose triple therapy to reduce side effects of eradicating Helicobacter pylori. Am J Gastroenterol. 1994;89:33–38.

    PubMed  CAS  Google Scholar 

  10. Duggan AE, Tolley K, Hawkey CJ, Logan RFA. H. pylori eradication in duodenal ulcer disease: what determines cost effectiveness? Br Med J. 1998;316:1648–1654.

    Article  CAS  Google Scholar 

  11. Huwez FU, Thurlwell D, Cockayne A, Ala-Aldeen DA. Mastic gum kills Helicobacter pylori. N Engl J Med. 1998;339:1946.

    Article  PubMed  Google Scholar 

  12. Lee M, Kern JA, Canning A, Egan C, Tataronis G, Francis F. A randomized controlled trial of an enhanced patient compliance programme for Helicobacter pylori therapy. Arch Intern Med. 1999;159:2312–2316.

    Article  PubMed  CAS  Google Scholar 

  13. Henry A, Batey RG. Enhancing compliance not a prerequisite for effective eradication of Helicobacter pylori: the HelP Study. Am J Gastroenterol. 1999;94:811–815.

    Article  PubMed  CAS  Google Scholar 

  14. Megraud F. Risk factors for failures. In: Hunt RH, Tytgat GJ, editors. Helicobacter pylori: Basic Mechanisms to Clinical Cure 2000; this volume.

    Google Scholar 

  15. Hazell S. What are the biochemical and physiological implications of the new genetic information? In: Hunt RH, Tytgat GJ, editors. Helicobacter pylori: Basic Mechanisms to Clinical Cure 2000; this volume.

    Google Scholar 

  16. Marais A, Mendz GL, Hazell SL, Megraud F. Metabolism and genetics of Helicobacter pylori: the genome era. Microbiol Mol Biol Rev. 1999;63:642–674.

    PubMed  CAS  Google Scholar 

  17. Tomb J-F, White O, Kerlavage AR et al. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature. 1997;388:539–547.

    Article  PubMed  CAS  Google Scholar 

  18. Alm RA, Ling L-SL, Moir DT et al. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature. 1999;397:176–180.

    Article  PubMed  Google Scholar 

  19. O’Toole PW, Janzon L, Doig P, Huang J, Kostrzynska M, Trust TJ. The putative neura-minyllactose-binding hemagglutinin HpaA of Helicobacter pylori CCUG 17874 is a lipoprotein. J Bacteriol. 1995;177:6049–6057.

    CAS  Google Scholar 

  20. Boren T, Roth KA, Larson G, Normark S. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science. 1993;262:1892–1895.

    Article  PubMed  CAS  Google Scholar 

  21. Zopf D, Roth S. Oligosaccharide anti-infective agents. Lancet. 1996;347:1017–1021.

    Article  PubMed  CAS  Google Scholar 

  22. Sachs G. Urease regulations. In: Hunt RH, Tytgat GJ editors. Helicobacter pylori: Basic Mechanisms to Clinical Cure 2000; this volume.

    Google Scholar 

  23. Jackson CJ, Kelly DJ, Clayton CL. The cloning and characterization of chemotaxis genes in Helicobacter pylori. Gut. 1995;37:A71.

    Article  Google Scholar 

  24. O’Toole PW, Kostrazynska M, Trust TJ. Non-mobile mutants of Helicobacter pylori and Helicobacter mustelae defective in flagellar hood production. Mol Microbiol. 1994,14:691–703.

    Article  CAS  Google Scholar 

  25. Sega ED, Cha J, Falkow S, Tompkins LS. Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori Proc Natl Acad Sci USA. 1999;96:14559–14564.

    Article  Google Scholar 

  26. Mysore JC, Wiggington T, Simon PM, Zopf D, Heman-Ackah LM, Dubois A. Treatment of Helicobacter pylori infection in rhesus monkeys using a novel antiadhesion compound. Gastroenterology. 1999;117:1316–1325.

    Article  PubMed  CAS  Google Scholar 

  27. Graham DY., vacA, cagA, iceA and babA are not useful for assessing H. pylori virulence. In: Hunt RH, Tytgat GJ, editors. Helicobacter pylori: Basic Mechanisms to Clinical Cure. 2000; this volume.

    Google Scholar 

  28. Duggan AE, Elliott C, Hawkey CJ, Logan RFA. Randomised controlled trial of four dyspepsia management strategies in primary care with 12 months follow-up. Gastroenterology. 2000 (In press).

    Google Scholar 

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Hawkey, C.J. (2000). Helicobacter pylori infection: expectations for future therapy. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3927-4_69

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  • DOI: https://doi.org/10.1007/978-94-011-3927-4_69

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5753-0

  • Online ISBN: 978-94-011-3927-4

  • eBook Packages: Springer Book Archive

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