Further Considerations on the Cellular Mechanisms of Neuronal Plasticity

  • L. Kerkerian-Le Goff
  • A. Daszuta
  • A. Nieoullon
Chapter
Part of the NATO ASI Series book series (ASID, volume 62)

Abstract

Recent evidences indicate that functional recovery after brain injury in adults is dependent on extreme adaptive capacities of mature neuronal circuits. Neuroplasticity at the cellular level would involve three sets of mechanisms referring to structural, metabolic and genomic adaptive changes. Most of studies have examined the effects of elimination of afferent pathways to particular brain regions and more recently the effects of intracerebral transplantations. For a long time, neuroplasticity then appeared as a compensatory structural or functional reorganization of neuronal networks triggered by brain damage. However, the concept has recently emerged that the adaptive capacities of the adult brain at cellular level are also expressed in the absence of denervation, and would represent a basic mechanism for learning and memory processes as well as for behavioural adjustements to permanent changes in the external context.

Keywords

Adaptive Capacity Brain Damage Structural Reorganization Target Neuron Mammalian Central Nervous System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media Dordrecht 1991

Authors and Affiliations

  • L. Kerkerian-Le Goff
    • 1
  • A. Daszuta
    • 1
  • A. Nieoullon
    • 1
  1. 1.Neurochemistry UnitCNRS Laboratory of Functional NeuroscienceMarseille cedex 9France

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