Amyloid and Amyloidosis 1990 pp 303-306 | Cite as
Induction of Amyloid Deposition by Subfractions of the Amyloid Enhancing Factor Extracted from Brain of Patients with Alzheimer’s Disease
Chapter
Abstract
Crude amyloid enhancing factor (AEF) was extracted from brain samples of patients with Alzheimer’s disease (AD) and showed to be capable of inducing amyloidosis. This crude AEF extract was electrophoresed and seven fractions of different molecular weights were isolated by electroelution. Only two out of these seven fractions were found to have AEF activity; one fraction contained high molecular weight proteins (> 90 kDa) and the other was of lower molecular weight (21.5 to 30 kDa). These two fractions could induce accelerated amyloid deposition in experimental animals.
Keywords
Familial Mediterranean Fever Amyloid Deposition High Molecular Weight Protein Major Protein Band Cerebral Amyloidosis
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© Springer Science+Business Media Dordrecht 1991